FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066685917> ?p ?o ?g. }

• W2066685917 endingPage "L169" @default.
• W2066685917 startingPage "L162" @default.
• W2066685917 abstract "Limitation of reactive oxygen species-mediated ischemia-reperfusion (I/R) injury of the lung by vascular immunotargeting of antioxidative enzymes has the potential to become a promising modality for extension of the viability of banked transplantation tissue. The preferential expression of angiotensin-converting enzyme (ACE) in pulmonary capillaries makes it an ideal target for therapy directed toward the pulmonary endothelium. Conjugates of ACE monoclonal antibody (MAb) 9B9 with catalase (9B9-CAT) have been evaluated in vivo for limitation of lung I/R injury in rats. Ischemia of the right lung was induced for 60 min followed by 120 min of reperfusion. Sham-operated animals (sham, n = 6) were compared with ischemia-reperfused untreated animals (I/R, n = 6), I/R animals treated with biotinylated catalase (CAT, n = 6), and I/R rats treated with the conjugates (9B9-CAT, n = 6). The 9B9-CAT accumulation in the pulmonary endothelium of injured lungs was elucidated immunohistochemically. Arterial oxygenation during reperfusion was significantly higher in 9B9-CAT (221 ± 36 mmHg) and sham (215 ± 16 mmHg; P < 0.001 for both) compared with I/R (110 ± 10 mmHg) and CAT (114 ± 30 mmHg). Wet-dry weight ratio of I/R (6.78 ± 0.94%) and CAT (6.54 ± 0.87%) was significantly higher than of sham (4.85 ± 0.29%; P < 0.05), which did not differ from 9B9-CAT (5.58 ± 0.80%). The significantly lower degree of lung injury in 9B9-CAT-treated animals compared with I/R rats was also shown by decreased serum levels of endothelin-1 (sham, 18 ± 9 fmol/mg; I/R, 42 ± 12 fmol/mg; CAT, 36 ± 11 fmol/mg; 9B9-CAT, 26 ± 9 fmol/mg; P < 0.01) and mRNA for inducible nitric oxide synthase (iNOS) [iNOS-GAPDH ratio: sham, 0.15 ± 0.06 arbitrary units (a.u.); I/R, 0.33 ± 0.08 a.u.; CAT, 0.26 ± 0.05 a.u.; 9B9-CAT, 0.14 ± 0.04 a.u.; P < 0.001]. These results validate immunotargeting by anti-ACE conjugates as a prospective and specific strategy to augment antioxidative defenses of the pulmonary endothelium in vivo." @default.
• W2066685917 created "2016-06-24" @default.
• W2066685917 creator A5005796927 @default.
• W2066685917 creator A5014314166 @default.
• W2066685917 creator A5015781558 @default.
• W2066685917 creator A5027721487 @default.
• W2066685917 creator A5033885411 @default.
• W2066685917 creator A5046601855 @default.
• W2066685917 creator A5048047454 @default.
• W2066685917 creator A5090478909 @default.
• W2066685917 date "2007-07-01" @default.
• W2066685917 modified "2023-09-24" @default.
• W2066685917 title "Immunotargeting of catalase to lung endothelium via anti-angiotensin-converting enzyme antibodies attenuates ischemia-reperfusion injury of the lung in vivo" @default.
• W2066685917 cites W142851431 @default.
• W2066685917 cites W1907762214 @default.
• W2066685917 cites W1963697143 @default.
• W2066685917 cites W1967403730 @default.
• W2066685917 cites W1972145808 @default.
• W2066685917 cites W1976648730 @default.
• W2066685917 cites W1978391058 @default.
• W2066685917 cites W1980863845 @default.
• W2066685917 cites W1983129889 @default.
• W2066685917 cites W1983688860 @default.
• W2066685917 cites W1995110990 @default.
• W2066685917 cites W1996892136 @default.
• W2066685917 cites W2000549992 @default.
• W2066685917 cites W2014439221 @default.
• W2066685917 cites W2015416175 @default.
• W2066685917 cites W2017955760 @default.
• W2066685917 cites W2029327309 @default.
• W2066685917 cites W2046046896 @default.
• W2066685917 cites W2047849255 @default.
• W2066685917 cites W2051297164 @default.
• W2066685917 cites W2053418020 @default.
• W2066685917 cites W2058021647 @default.
• W2066685917 cites W2068259926 @default.
• W2066685917 cites W2080376445 @default.
• W2066685917 cites W2089475265 @default.
• W2066685917 cites W2101563821 @default.
• W2066685917 cites W2113572683 @default.
• W2066685917 cites W2115734416 @default.
• W2066685917 cites W2137776239 @default.
• W2066685917 cites W2142197498 @default.
• W2066685917 cites W2146149181 @default.
• W2066685917 cites W2149855017 @default.
• W2066685917 cites W2155900030 @default.
• W2066685917 cites W2172002898 @default.
• W2066685917 cites W2184443404 @default.
• W2066685917 cites W2222042791 @default.
• W2066685917 cites W2312792640 @default.
• W2066685917 cites W2319559938 @default.
• W2066685917 cites W2405996794 @default.
• W2066685917 cites W2409499476 @default.
• W2066685917 cites W4249702593 @default.
• W2066685917 cites W47438373 @default.
• W2066685917 doi "https://doi.org/10.1152/ajplung.00001.2007" @default.
• W2066685917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17435080" @default.
• W2066685917 hasPublicationYear "2007" @default.
• W2066685917 type Work @default.
• W2066685917 sameAs 2066685917 @default.
• W2066685917 citedByCount "47" @default.
• W2066685917 countsByYear W20666859172012 @default.
• W2066685917 countsByYear W20666859172013 @default.
• W2066685917 countsByYear W20666859172014 @default.
• W2066685917 countsByYear W20666859172015 @default.
• W2066685917 countsByYear W20666859172016 @default.
• W2066685917 countsByYear W20666859172017 @default.
• W2066685917 countsByYear W20666859172018 @default.
• W2066685917 countsByYear W20666859172019 @default.
• W2066685917 countsByYear W20666859172020 @default.
• W2066685917 countsByYear W20666859172021 @default.
• W2066685917 crossrefType "journal-article" @default.
• W2066685917 hasAuthorship W2066685917A5005796927 @default.
• W2066685917 hasAuthorship W2066685917A5014314166 @default.
• W2066685917 hasAuthorship W2066685917A5015781558 @default.
• W2066685917 hasAuthorship W2066685917A5027721487 @default.
• W2066685917 hasAuthorship W2066685917A5033885411 @default.
• W2066685917 hasAuthorship W2066685917A5046601855 @default.
• W2066685917 hasAuthorship W2066685917A5048047454 @default.
• W2066685917 hasAuthorship W2066685917A5090478909 @default.
• W2066685917 hasConcept C126322002 @default.
• W2066685917 hasConcept C134018914 @default.
• W2066685917 hasConcept C150903083 @default.
• W2066685917 hasConcept C185592680 @default.
• W2066685917 hasConcept C207001950 @default.
• W2066685917 hasConcept C2776151105 @default.
• W2066685917 hasConcept C2777714996 @default.
• W2066685917 hasConcept C2778979269 @default.
• W2066685917 hasConcept C2780114680 @default.
• W2066685917 hasConcept C2781448352 @default.
• W2066685917 hasConcept C2911091166 @default.
• W2066685917 hasConcept C541997718 @default.
• W2066685917 hasConcept C71924100 @default.
• W2066685917 hasConcept C86803240 @default.
• W2066685917 hasConcept C98274493 @default.
• W2066685917 hasConceptScore W2066685917C126322002 @default.
• W2066685917 hasConceptScore W2066685917C134018914 @default.
• W2066685917 hasConceptScore W2066685917C150903083 @default.

• next