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- W2066696887 abstract "Severe acute pancreatitis has many similarities to sepsis syndrome and septic shock. The haemodynamic features of cardiovascular instability, reduced ejection fraction and decreased systemic vascular resistance are indistinguishable in each of these conditions. In addition there are many striking similarities in the cytokine and inflammatory mediator profiles, suggesting that the haemodynamic abnormalities may result from the same pathogenic mechanisms, albeit as a result of different inflammatory stimuli. Although septic complications of severe acute pancreatitis do arise these are usually late features and in the early phase of a severe attack there is sterile pancreatic necrosis. Evidence suggests that the important cytokines in the development of complications and multiple organ failure in severe acute pancreatitis are tumour necrosis factor-alpha, interleukin-1, interleukin-6 and interleukin-8. In addition, endotoxin and other important inflammatory mediators including platelet activating factor and phospholipase A2 are implicated in the development of complications in both severe acute pancreatitis and sepsis. Patients with severe acute pancreatitis are not an entirely homogeneous group but in terms of pathogenesis and complications of their disease they have much more in common with each other than the patients who are collected under the unifying diagnosis of 'sepsis'. The similar clinical and biochemical features between severe acute pancreatitis and sepsis make the former an excellent model for studying the pathogenesis of the sepsis syndrome." @default.
- W2066696887 created "2016-06-24" @default.
- W2066696887 creator A5029810863 @default.
- W2066696887 creator A5050618565 @default.
- W2066696887 creator A5052825850 @default.
- W2066696887 date "1998-01-01" @default.
- W2066696887 modified "2023-10-18" @default.
- W2066696887 title "Acute pancreatitis as a model of sepsis" @default.
- W2066696887 cites W112984908 @default.
- W2066696887 cites W1511769880 @default.
- W2066696887 cites W1552669957 @default.
- W2066696887 cites W1598937331 @default.
- W2066696887 cites W1607661535 @default.
- W2066696887 cites W177403107 @default.
- W2066696887 cites W1799056643 @default.
- W2066696887 cites W180338758 @default.
- W2066696887 cites W1821310675 @default.
- W2066696887 cites W1833085377 @default.
- W2066696887 cites W1852718176 @default.
- W2066696887 cites W1857396158 @default.
- W2066696887 cites W1879207397 @default.
- W2066696887 cites W1886020135 @default.
- W2066696887 cites W1929579570 @default.
- W2066696887 cites W1967207135 @default.
- W2066696887 cites W1967578063 @default.
- W2066696887 cites W1973599912 @default.
- W2066696887 cites W1976400660 @default.
- W2066696887 cites W1976591203 @default.
- W2066696887 cites W1982273546 @default.
- W2066696887 cites W1985045980 @default.
- W2066696887 cites W1986880424 @default.
- W2066696887 cites W1991011107 @default.
- W2066696887 cites W1992999956 @default.
- W2066696887 cites W1993947411 @default.
- W2066696887 cites W1994520070 @default.
- W2066696887 cites W1994824685 @default.
- W2066696887 cites W1995449591 @default.
- W2066696887 cites W1996548067 @default.
- W2066696887 cites W2001819213 @default.
- W2066696887 cites W2001847823 @default.
- W2066696887 cites W2005149171 @default.
- W2066696887 cites W2006367658 @default.
- W2066696887 cites W2011291552 @default.
- W2066696887 cites W2011460762 @default.
- W2066696887 cites W2016083493 @default.
- W2066696887 cites W2017223857 @default.
- W2066696887 cites W2022267481 @default.
- W2066696887 cites W2024602632 @default.
- W2066696887 cites W2026936598 @default.
- W2066696887 cites W2027334026 @default.
- W2066696887 cites W2029069606 @default.
- W2066696887 cites W2029559453 @default.
- W2066696887 cites W2029848330 @default.
- W2066696887 cites W2031944053 @default.
- W2066696887 cites W2034797939 @default.
- W2066696887 cites W2038838714 @default.
- W2066696887 cites W2039739386 @default.
- W2066696887 cites W2040031769 @default.
- W2066696887 cites W2045010042 @default.
- W2066696887 cites W2045100233 @default.
- W2066696887 cites W2050515690 @default.
- W2066696887 cites W2052896018 @default.
- W2066696887 cites W2057807822 @default.
- W2066696887 cites W2058312694 @default.
- W2066696887 cites W2059146195 @default.
- W2066696887 cites W2059348849 @default.
- W2066696887 cites W2060444492 @default.
- W2066696887 cites W2064309187 @default.
- W2066696887 cites W2064765612 @default.
- W2066696887 cites W2068103783 @default.
- W2066696887 cites W2071485163 @default.
- W2066696887 cites W2072026692 @default.
- W2066696887 cites W2072737535 @default.
- W2066696887 cites W2074570851 @default.
- W2066696887 cites W2077754412 @default.
- W2066696887 cites W2086226482 @default.
- W2066696887 cites W2088734986 @default.
- W2066696887 cites W2088847409 @default.
- W2066696887 cites W2090049120 @default.
- W2066696887 cites W2091989722 @default.
- W2066696887 cites W2094367973 @default.
- W2066696887 cites W2094465311 @default.
- W2066696887 cites W2101157641 @default.
- W2066696887 cites W2108114770 @default.
- W2066696887 cites W2114784836 @default.
- W2066696887 cites W2118358728 @default.
- W2066696887 cites W2123884323 @default.
- W2066696887 cites W2130893526 @default.
- W2066696887 cites W2132479898 @default.
- W2066696887 cites W2134674910 @default.
- W2066696887 cites W2148583002 @default.
- W2066696887 cites W2163254761 @default.
- W2066696887 cites W2166542918 @default.
- W2066696887 cites W2182204751 @default.
- W2066696887 cites W2206320968 @default.
- W2066696887 cites W2233541602 @default.
- W2066696887 cites W2340153383 @default.
- W2066696887 cites W2404113641 @default.