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• W2066698911 abstract "The early, prenatal formation of noradrenergic projections to the forebrain has led to the proposition that these axons exert a trophic influence on cerebral cortex during ontogeny. To test this hypothesis, we have examined a number of different structural features of cortical development following prenatal lesions of the ascending noradrenergic axons. The parameters that were analyzed include cytoarchitecture, dendritic morphology, and the distribution of monoaminergic and nonmonoaminergic cortical afferents. Rat fetuses were administered the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) by transuterine, intraperitoneal injection on embryonic day 17. Vehicle-injected controls and fetuses treated with the catecholamine uptake inhibitor desmethylimipramine (DMI) prior to 6-OHDA were prepared. After reaching maturity (200–300 g), the brains of treated and control rats were examined using Niss1 and Golgi preparations (for cytoarchitecture and dendritic morphology), histofluorescence (for monoaminergic afferents, especially dopaminergic axons), and serotonin and dopamine-β-hydroxylase (DBH) immunocytochemistry. Effective lesioning of the ascending noradrenergic system was confirmed in each case, using DBH immunocytochemistry. Prenatal treatment with 6-OHDA resulted in complete and long-lasting destruction of the noradrenergic innervation of the cerebral cortex, along with hyperinnervation of the diencephalon and brain stem. Despite the widespread denervation of cerebral cortex, no significant alterations in cytoarchitecture, dendritic morphology, or spine counts were found in treated brains. In particular, no abnormalities were observed in the apical dendrites of layer VI pyramidal cells, based on qualitative criteria. The distribution, density and morphology of serotonergic and dopaminergic afferents were unaffected. Thalamocortical afferents had developed normally as reflected by the cortical barrels. In 33% of the 6-OHDA-treated fetuses foci of ectopic neurons were found at the cortical surface. The ectopias contain neuronal processes, somata, and synapses interspersed with collagen and other connective tissue elements. While the ectopias may result from selective damage to the noradrenergic neurons, the finding of similar (but smaller) malformations in DMI-protected animals is equally consistent with a non-specific effect of 6-OHDA upon non-adrenergic cells. The examination of intervening stages will be needed to resolve this question. Based on the parameters of cortical structure analyzed in this study we conclude that the neocortex develops normally even in the absence of the noradrenergic system." @default.
• W2066698911 created "2016-06-24" @default.
• W2066698911 creator A5053894121 @default.
• W2066698911 creator A5081923445 @default.
• W2066698911 date "1982-01-01" @default.
• W2066698911 modified "2023-10-12" @default.
• W2066698911 title "The structure of cerebral cortex in the rat following prenatal administration of 6-hydroxydopamine" @default.
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• W2066698911 cites W1965756220 @default.
• W2066698911 cites W1968227329 @default.
• W2066698911 cites W1968642771 @default.
• W2066698911 cites W1970008377 @default.
• W2066698911 cites W1970342966 @default.
• W2066698911 cites W1972673847 @default.
• W2066698911 cites W1974391609 @default.
• W2066698911 cites W1976229306 @default.
• W2066698911 cites W1977170192 @default.
• W2066698911 cites W1978981223 @default.
• W2066698911 cites W1979260077 @default.
• W2066698911 cites W1980274515 @default.
• W2066698911 cites W1980275914 @default.
• W2066698911 cites W1985142350 @default.
• W2066698911 cites W1991053160 @default.
• W2066698911 cites W1995285208 @default.
• W2066698911 cites W1996595977 @default.
• W2066698911 cites W1998499663 @default.
• W2066698911 cites W2001629870 @default.
• W2066698911 cites W2010055561 @default.
• W2066698911 cites W2011411831 @default.
• W2066698911 cites W2018297305 @default.
• W2066698911 cites W2018409181 @default.
• W2066698911 cites W2019180047 @default.
• W2066698911 cites W2019402991 @default.
• W2066698911 cites W2021330687 @default.
• W2066698911 cites W2027586363 @default.
• W2066698911 cites W2030986484 @default.
• W2066698911 cites W2032029885 @default.
• W2066698911 cites W2033505667 @default.
• W2066698911 cites W2033762971 @default.
• W2066698911 cites W2034434531 @default.
• W2066698911 cites W2034684185 @default.
• W2066698911 cites W2035830471 @default.
• W2066698911 cites W2037044452 @default.
• W2066698911 cites W2039202512 @default.
• W2066698911 cites W2039784596 @default.
• W2066698911 cites W2040297612 @default.
• W2066698911 cites W2042226507 @default.
• W2066698911 cites W2042543545 @default.
• W2066698911 cites W2043417320 @default.
• W2066698911 cites W2044320138 @default.
• W2066698911 cites W2045295673 @default.
• W2066698911 cites W2049124024 @default.
• W2066698911 cites W2052699392 @default.
• W2066698911 cites W2052972151 @default.
• W2066698911 cites W2057352698 @default.
• W2066698911 cites W2057914634 @default.
• W2066698911 cites W2061453997 @default.
• W2066698911 cites W2062175223 @default.
• W2066698911 cites W2063242000 @default.
• W2066698911 cites W2068337437 @default.
• W2066698911 cites W2069129963 @default.
• W2066698911 cites W2069617695 @default.
• W2066698911 cites W2071268880 @default.
• W2066698911 cites W2075436069 @default.
• W2066698911 cites W2076176412 @default.
• W2066698911 cites W2078201992 @default.
• W2066698911 cites W2078885383 @default.
• W2066698911 cites W2082333529 @default.
• W2066698911 cites W2110334069 @default.
• W2066698911 cites W2113827256 @default.
• W2066698911 cites W2122427440 @default.
• W2066698911 cites W2124984337 @default.
• W2066698911 cites W2127939929 @default.
• W2066698911 cites W2131784975 @default.
• W2066698911 cites W2142303954 @default.
• W2066698911 cites W2144561988 @default.
• W2066698911 cites W2149346422 @default.
• W2066698911 cites W4247067925 @default.
• W2066698911 doi "https://doi.org/10.1016/0165-3806(82)90077-3" @default.
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