Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066702528> ?p ?o ?g. }
- W2066702528 endingPage "12" @default.
- W2066702528 startingPage "1" @default.
- W2066702528 abstract "Hyperlipidemia is frequently associated with insulin resistance states as found in type 2 diabetes and obesity. Effects of free fatty acids (FFA) on pancreatic beta-cells have long been recognized. Acute exposure of the pancreatic beta-cell to FFA results in an increase of insulin release, whereas a chronic exposure results in desensitization and suppression of secretion. We recently showed that palmitate augments insulin release in the presence of non-stimulatory concentrations of glucose. Reduction of plasma FFA levels in fasted rats or humans severely impairs glucose-induced insulin release. These results imply that physiological plasma levels of FFA are important for beta-cell function. Although, it has been accepted that fatty acid oxidation is necessary for its stimulation of insulin secretion, the possible mechanisms by which fatty acids (FA) affect insulin secretion are discussed in this review. Long-chain acyl-CoA (LC-CoA) controls several aspects of the beta-cell function including activation of certain types of protein kinase C (PKC), modulation of ion channels, protein acylation, ceramide- and/or nitric oxide (NO)-mediated apoptosis, and binding to nuclear transcriptional factors. The present review also describes the possible effects of FA on insulin signaling. We showed for the first time that acute exposure of islets to palmitate upregulates the intracellular insulin-signaling pathway in pancreatic islets. Another aspect considered in this review is the source of FA for pancreatic islets. In addition to be exported to the medium, lipids can be transferred from leukocytes (macrophages) to pancreatic islets in co-culture. This process consists an additional source of FA that may plays a significant role to regulate insulin secretion." @default.
- W2066702528 created "2016-06-24" @default.
- W2066702528 creator A5004080311 @default.
- W2066702528 creator A5009853570 @default.
- W2066702528 creator A5019832494 @default.
- W2066702528 creator A5066102381 @default.
- W2066702528 creator A5081846149 @default.
- W2066702528 creator A5087977609 @default.
- W2066702528 date "2002-11-08" @default.
- W2066702528 modified "2023-10-13" @default.
- W2066702528 title "Pleiotropic effects of fatty acids on pancreatic β-cells" @default.
- W2066702528 cites W1494227533 @default.
- W2066702528 cites W1499384204 @default.
- W2066702528 cites W1500111450 @default.
- W2066702528 cites W1514141833 @default.
- W2066702528 cites W1520054154 @default.
- W2066702528 cites W1536640324 @default.
- W2066702528 cites W1546970082 @default.
- W2066702528 cites W1572009433 @default.
- W2066702528 cites W1573536022 @default.
- W2066702528 cites W1603762978 @default.
- W2066702528 cites W1643947316 @default.
- W2066702528 cites W1750774965 @default.
- W2066702528 cites W1773327886 @default.
- W2066702528 cites W1794038664 @default.
- W2066702528 cites W1843461492 @default.
- W2066702528 cites W1897115642 @default.
- W2066702528 cites W1908005108 @default.
- W2066702528 cites W1910635175 @default.
- W2066702528 cites W1940095969 @default.
- W2066702528 cites W1961993092 @default.
- W2066702528 cites W1965005201 @default.
- W2066702528 cites W1967206579 @default.
- W2066702528 cites W1973611043 @default.
- W2066702528 cites W1973837499 @default.
- W2066702528 cites W1974075629 @default.
- W2066702528 cites W1975088924 @default.
- W2066702528 cites W1978686382 @default.
- W2066702528 cites W1980412576 @default.
- W2066702528 cites W1980725505 @default.
- W2066702528 cites W1981072221 @default.
- W2066702528 cites W1981747327 @default.
- W2066702528 cites W1982438897 @default.
- W2066702528 cites W1984231873 @default.
- W2066702528 cites W1985077083 @default.
- W2066702528 cites W1985149672 @default.
- W2066702528 cites W1988173933 @default.
- W2066702528 cites W1990607115 @default.
- W2066702528 cites W1991825108 @default.
- W2066702528 cites W1992968276 @default.
- W2066702528 cites W1997129347 @default.
- W2066702528 cites W1999155329 @default.
- W2066702528 cites W1999557771 @default.
- W2066702528 cites W2000977514 @default.
- W2066702528 cites W2002711503 @default.
- W2066702528 cites W2003625850 @default.
- W2066702528 cites W2005688198 @default.
- W2066702528 cites W2006053538 @default.
- W2066702528 cites W2008291690 @default.
- W2066702528 cites W2009184816 @default.
- W2066702528 cites W2010523407 @default.
- W2066702528 cites W2011024261 @default.
- W2066702528 cites W2012898950 @default.
- W2066702528 cites W2014390235 @default.
- W2066702528 cites W2014792924 @default.
- W2066702528 cites W2015543883 @default.
- W2066702528 cites W2015813060 @default.
- W2066702528 cites W2017499074 @default.
- W2066702528 cites W2017619481 @default.
- W2066702528 cites W2017783641 @default.
- W2066702528 cites W2020468088 @default.
- W2066702528 cites W2022294953 @default.
- W2066702528 cites W2022336683 @default.
- W2066702528 cites W2024035381 @default.
- W2066702528 cites W2024306318 @default.
- W2066702528 cites W2029410945 @default.
- W2066702528 cites W2029911977 @default.
- W2066702528 cites W2030153054 @default.
- W2066702528 cites W2030573603 @default.
- W2066702528 cites W2030768859 @default.
- W2066702528 cites W2034368055 @default.
- W2066702528 cites W2035111864 @default.
- W2066702528 cites W2035843625 @default.
- W2066702528 cites W2036344921 @default.
- W2066702528 cites W2036848107 @default.
- W2066702528 cites W2037085464 @default.
- W2066702528 cites W2037393740 @default.
- W2066702528 cites W2037802736 @default.
- W2066702528 cites W2039531356 @default.
- W2066702528 cites W2039531779 @default.
- W2066702528 cites W2040595653 @default.
- W2066702528 cites W2040692229 @default.
- W2066702528 cites W2041611018 @default.
- W2066702528 cites W2042891307 @default.
- W2066702528 cites W2043868386 @default.
- W2066702528 cites W2044736728 @default.
- W2066702528 cites W2045956369 @default.
- W2066702528 cites W2046208788 @default.