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- W2066702589 abstract "Vitamin D deficiency maybe more prevalent among HIV-positive patients than in the general populationdue to HIV disease-related factors. This study examined the effects of HIVinfection and use of antiretroviral drugs in serum vitamin D levels in HIVpatients visiting Aga Khan University Hospital, Nairobi Kenya from October 2013to April 2014. The effect of vitamin D status on CD4 cell count and HIV viral load wasevaluated to determine the status of disease progression to AIDS. HIV viralload in blood samples was determined using COBAS Ampliprep/TaqMan HIV-1 testkit while CD4 cellcounts were done using the fluorescence-activated cell sorter system. Thelevels of vitamin D in serum were determined using electrochemiluminescencebinding assay in Cobas E601 mass analyzers. In addition, selected plasmaenzymes were used to evaluate liver function. Higher percentage (49.12%) ofdeficient vitamin D cases were observed among HIV patients not on ART.Deficient levels of Vitamin D were associated with abnormal selected liverenzymes. High viral load was observed among patients not on ART with deficientand insufficient vitamin D. The CD4 cell count was higher in patients onART with sufficient vitamin D levels compared to those with deficient vitaminD. These observations suggest a need to supplement ART with vitamin D in orderto ameliorate Vitamin D deficiency as a strategy to improve HIV management." @default.
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- W2066702589 date "2014-01-01" @default.
- W2066702589 modified "2023-09-26" @default.
- W2066702589 title "Studies on Vitamin D Levels in Serum of HIV Infected Patients: Their Effect on Progression towards AIDS" @default.
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- W2066702589 doi "https://doi.org/10.4236/wja.2014.44050" @default.
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