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- W2066702812 abstract "The ability of pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine1A/1B antagonist, to enhance the clinical antidepressant response to selective serotonin re-uptake inhibitors is generally attributed to a blocking of the feedback that inhibits the serotoninergic neuronal activity mediated by somatodendritic 5-hydroxytryptamine (5-HT)1A autoreceptors. The current study examined the ability of pindolol to enhance the analgesic effect of tramadol, an atypical centrally-acting analgesic agent with relatively weak opioid receptor affinity and which, like some antidepressants, is able to inhibit the re-uptake of 5-HT in the raphe nuclei. Racemic pindolol (2 mg/kg, s.c.), rendered analgesic a non-effective acute dose of tramadol (10–40 mg/kg, i.p.) in two nociceptive tests: a hot plate test in mice and a plantar test in rats. Moreover, (±)8-OH-DPAT (0.125–1 mg/kg, s.c.), a selective 5-HT1A agonist, reduces the analgesic effect of tramadol in the same tests. These results suggest an implication of the somatodendritic 5-HT1A receptors in the analgesic effect of tramadol and open a new adjuvant analgesic strategy for the use of this compound." @default.
- W2066702812 created "2016-06-24" @default.
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- W2066702812 date "2000-11-01" @default.
- W2066702812 modified "2023-10-17" @default.
- W2066702812 title "Pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine1A/1B antagonist, enhances the analgesic effect of tramadol" @default.
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- W2066702812 doi "https://doi.org/10.1016/s0304-3959(00)00299-2" @default.
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