Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066702956> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2066702956 endingPage "191" @default.
- W2066702956 startingPage "187" @default.
- W2066702956 abstract "The mechanism(s) underlying respiratory sensitivity to chemicals is uncertain but is assumed to involve immunologic components with pharmacologic and neurologic involvement. Predictive testing would be valuable to prevent occurrence of hypersensitivity. Several in vitro and in vivo approaches have been used for predictive purposes. In vitro methods have included assessment of the ability of the chemical to undergo reaction with proteins. Computational methods have investigated the relationship between structure and electrophilic potential of chemical allergens. We have initiated a structure-activity evaluation of chemicals associated with elicitation of respiratory sensitization and have utilized a computer-based expert system, MultiCASE. A preliminary database of 39 active chemicals has been established from a literature search of clinical case reports and animal test results. Evaluation of the model has indicated structural alerts for activity which consist of structural fragments as well as physicochemical properties. Further development of the model and evaluation of findings should enable mechanistic insight into the process of respiratory sensitization and recognition of factors which distinguish respiratory sensitizers mechanistically from other chemical allergens such as contact sensitizing chemicals." @default.
- W2066702956 created "2016-06-24" @default.
- W2066702956 creator A5000084505 @default.
- W2066702956 creator A5015583050 @default.
- W2066702956 creator A5032795415 @default.
- W2066702956 creator A5053409997 @default.
- W2066702956 creator A5073709590 @default.
- W2066702956 creator A5080505734 @default.
- W2066702956 date "1996-08-01" @default.
- W2066702956 modified "2023-09-26" @default.
- W2066702956 title "Structure-activity relationships and computer-assisted analysis of respiratory sensitization potential" @default.
- W2066702956 cites W1966785965 @default.
- W2066702956 cites W1998323609 @default.
- W2066702956 cites W2002784026 @default.
- W2066702956 cites W2021905476 @default.
- W2066702956 cites W2030373084 @default.
- W2066702956 cites W2035080459 @default.
- W2066702956 cites W2051212754 @default.
- W2066702956 cites W2067049076 @default.
- W2066702956 cites W2084425364 @default.
- W2066702956 cites W2169204622 @default.
- W2066702956 cites W2326369172 @default.
- W2066702956 doi "https://doi.org/10.1016/0378-4274(96)03689-2" @default.
- W2066702956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8711771" @default.
- W2066702956 hasPublicationYear "1996" @default.
- W2066702956 type Work @default.
- W2066702956 sameAs 2066702956 @default.
- W2066702956 citedByCount "46" @default.
- W2066702956 countsByYear W20667029562013 @default.
- W2066702956 countsByYear W20667029562014 @default.
- W2066702956 countsByYear W20667029562017 @default.
- W2066702956 countsByYear W20667029562020 @default.
- W2066702956 countsByYear W20667029562021 @default.
- W2066702956 crossrefType "journal-article" @default.
- W2066702956 hasAuthorship W2066702956A5000084505 @default.
- W2066702956 hasAuthorship W2066702956A5015583050 @default.
- W2066702956 hasAuthorship W2066702956A5032795415 @default.
- W2066702956 hasAuthorship W2066702956A5053409997 @default.
- W2066702956 hasAuthorship W2066702956A5073709590 @default.
- W2066702956 hasAuthorship W2066702956A5080505734 @default.
- W2066702956 hasConcept C126322002 @default.
- W2066702956 hasConcept C127413603 @default.
- W2066702956 hasConcept C150903083 @default.
- W2066702956 hasConcept C164126121 @default.
- W2066702956 hasConcept C183696295 @default.
- W2066702956 hasConcept C185592680 @default.
- W2066702956 hasConcept C203014093 @default.
- W2066702956 hasConcept C207001950 @default.
- W2066702956 hasConcept C2776217527 @default.
- W2066702956 hasConcept C3018346242 @default.
- W2066702956 hasConcept C534529494 @default.
- W2066702956 hasConcept C70721500 @default.
- W2066702956 hasConcept C71240020 @default.
- W2066702956 hasConcept C71924100 @default.
- W2066702956 hasConcept C86803240 @default.
- W2066702956 hasConceptScore W2066702956C126322002 @default.
- W2066702956 hasConceptScore W2066702956C127413603 @default.
- W2066702956 hasConceptScore W2066702956C150903083 @default.
- W2066702956 hasConceptScore W2066702956C164126121 @default.
- W2066702956 hasConceptScore W2066702956C183696295 @default.
- W2066702956 hasConceptScore W2066702956C185592680 @default.
- W2066702956 hasConceptScore W2066702956C203014093 @default.
- W2066702956 hasConceptScore W2066702956C207001950 @default.
- W2066702956 hasConceptScore W2066702956C2776217527 @default.
- W2066702956 hasConceptScore W2066702956C3018346242 @default.
- W2066702956 hasConceptScore W2066702956C534529494 @default.
- W2066702956 hasConceptScore W2066702956C70721500 @default.
- W2066702956 hasConceptScore W2066702956C71240020 @default.
- W2066702956 hasConceptScore W2066702956C71924100 @default.
- W2066702956 hasConceptScore W2066702956C86803240 @default.
- W2066702956 hasIssue "2-3" @default.
- W2066702956 hasLocation W20667029561 @default.
- W2066702956 hasLocation W20667029562 @default.
- W2066702956 hasOpenAccess W2066702956 @default.
- W2066702956 hasPrimaryLocation W20667029561 @default.
- W2066702956 hasRelatedWork W1973165925 @default.
- W2066702956 hasRelatedWork W2024874778 @default.
- W2066702956 hasRelatedWork W2047600549 @default.
- W2066702956 hasRelatedWork W2053663403 @default.
- W2066702956 hasRelatedWork W2113783751 @default.
- W2066702956 hasRelatedWork W2328604987 @default.
- W2066702956 hasRelatedWork W2344338575 @default.
- W2066702956 hasRelatedWork W2415635945 @default.
- W2066702956 hasRelatedWork W2617822300 @default.
- W2066702956 hasRelatedWork W4298221321 @default.
- W2066702956 hasVolume "86" @default.
- W2066702956 isParatext "false" @default.
- W2066702956 isRetracted "false" @default.
- W2066702956 magId "2066702956" @default.
- W2066702956 workType "article" @default.