Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066703419> ?p ?o ?g. }
- W2066703419 endingPage "660" @default.
- W2066703419 startingPage "652" @default.
- W2066703419 abstract "Abstract Partial left atrial ligation before cardiac septation redistributes intracardiac blood flow and produces left ventricular hypoplasia in the chick. We hypothesized that redistributed intracardiac blood flow adversely alters aortic arch development. We ligated the left atrial appendage with a 10‐0 nylon suture at stage 21 chick embryos, then reincubated up to stage 34. Sham embryos had a suture tied adjacent to the atrial wall, and normal controls were unoperated. We measured simultaneous atrioventricular (AV) and dorsal aortic (DAo) blood velocities from stage 24 embryos with an ultrasound pulsed‐Doppler flow meter; and the left and right third and fourth aortic arch blood flow with a laser‐Doppler flow meter. Ventricular and atrial cross‐sectional areas were measured from sequential video fields for planimetry. Intracardiac flow patterns were imaged on video by injecting India ink into the vitelline vein. In separate embryos, radiopaque microfil was injected into the cardiovascular system for μ‐CT scanning. We analyzed the morphologic characteristics of the heart at stage 34. Active AV and DAo stroke volume (mm 3 ), right third and fourth aortic arch blood flow (mm 3 /s) were all decreased in ligated embryos ( P < 0.05) when compared with normal and sham embryos. Ventricular end‐diastolic volume versus normal and sham embryos decreased by 45% and 46%, respectively ( P < 0.05). India ink injection revealed altered right aortic arch flow patterns in the ligated embryos compared with normal embryos. μ‐CT imaging confirmed altered arch morphogenesis. Alterations in intracardiac blood flow disrupt both early cardiac morphogenesis and aortic arch selection. Anat Rec, 2009. © 2009 Wiley‐Liss, Inc." @default.
- W2066703419 created "2016-06-24" @default.
- W2066703419 creator A5025841152 @default.
- W2066703419 creator A5037820174 @default.
- W2066703419 creator A5037910909 @default.
- W2066703419 creator A5037969585 @default.
- W2066703419 creator A5059652076 @default.
- W2066703419 creator A5087620238 @default.
- W2066703419 date "2009-03-25" @default.
- W2066703419 modified "2023-10-15" @default.
- W2066703419 title "Dependence of Aortic Arch Morphogenesis on Intracardiac Blood Flow in the Left Atrial Ligated Chick Embryo" @default.
- W2066703419 cites W1970521728 @default.
- W2066703419 cites W1973706332 @default.
- W2066703419 cites W1981157406 @default.
- W2066703419 cites W1984691692 @default.
- W2066703419 cites W1991656253 @default.
- W2066703419 cites W1995246957 @default.
- W2066703419 cites W2008199318 @default.
- W2066703419 cites W2023450190 @default.
- W2066703419 cites W2024657671 @default.
- W2066703419 cites W2034771251 @default.
- W2066703419 cites W2035536816 @default.
- W2066703419 cites W2040321811 @default.
- W2066703419 cites W2046882870 @default.
- W2066703419 cites W2060586833 @default.
- W2066703419 cites W2081441690 @default.
- W2066703419 cites W2087214853 @default.
- W2066703419 cites W2089500088 @default.
- W2066703419 cites W2096448056 @default.
- W2066703419 cites W2097208375 @default.
- W2066703419 cites W2103602547 @default.
- W2066703419 cites W2115704760 @default.
- W2066703419 cites W2132725598 @default.
- W2066703419 cites W2140034535 @default.
- W2066703419 cites W2143201804 @default.
- W2066703419 cites W2145994265 @default.
- W2066703419 cites W2147014354 @default.
- W2066703419 cites W2150258518 @default.
- W2066703419 cites W2150472293 @default.
- W2066703419 cites W2161987122 @default.
- W2066703419 cites W2162599637 @default.
- W2066703419 cites W2168164971 @default.
- W2066703419 cites W2170791805 @default.
- W2066703419 cites W2403255071 @default.
- W2066703419 cites W2403387058 @default.
- W2066703419 doi "https://doi.org/10.1002/ar.20885" @default.
- W2066703419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19322826" @default.
- W2066703419 hasPublicationYear "2009" @default.
- W2066703419 type Work @default.
- W2066703419 sameAs 2066703419 @default.
- W2066703419 citedByCount "51" @default.
- W2066703419 countsByYear W20667034192012 @default.
- W2066703419 countsByYear W20667034192013 @default.
- W2066703419 countsByYear W20667034192014 @default.
- W2066703419 countsByYear W20667034192015 @default.
- W2066703419 countsByYear W20667034192017 @default.
- W2066703419 countsByYear W20667034192018 @default.
- W2066703419 countsByYear W20667034192019 @default.
- W2066703419 countsByYear W20667034192020 @default.
- W2066703419 countsByYear W20667034192021 @default.
- W2066703419 countsByYear W20667034192022 @default.
- W2066703419 crossrefType "journal-article" @default.
- W2066703419 hasAuthorship W2066703419A5025841152 @default.
- W2066703419 hasAuthorship W2066703419A5037820174 @default.
- W2066703419 hasAuthorship W2066703419A5037910909 @default.
- W2066703419 hasAuthorship W2066703419A5037969585 @default.
- W2066703419 hasAuthorship W2066703419A5059652076 @default.
- W2066703419 hasAuthorship W2066703419A5087620238 @default.
- W2066703419 hasBestOaLocation W20667034191 @default.
- W2066703419 hasConcept C104317684 @default.
- W2066703419 hasConcept C105702510 @default.
- W2066703419 hasConcept C126322002 @default.
- W2066703419 hasConcept C145103041 @default.
- W2066703419 hasConcept C158846371 @default.
- W2066703419 hasConcept C164705383 @default.
- W2066703419 hasConcept C178853913 @default.
- W2066703419 hasConcept C196843134 @default.
- W2066703419 hasConcept C2779980429 @default.
- W2066703419 hasConcept C2781285907 @default.
- W2066703419 hasConcept C55493867 @default.
- W2066703419 hasConcept C7104941 @default.
- W2066703419 hasConcept C71924100 @default.
- W2066703419 hasConcept C80093799 @default.
- W2066703419 hasConcept C86803240 @default.
- W2066703419 hasConcept C95444343 @default.
- W2066703419 hasConceptScore W2066703419C104317684 @default.
- W2066703419 hasConceptScore W2066703419C105702510 @default.
- W2066703419 hasConceptScore W2066703419C126322002 @default.
- W2066703419 hasConceptScore W2066703419C145103041 @default.
- W2066703419 hasConceptScore W2066703419C158846371 @default.
- W2066703419 hasConceptScore W2066703419C164705383 @default.
- W2066703419 hasConceptScore W2066703419C178853913 @default.
- W2066703419 hasConceptScore W2066703419C196843134 @default.
- W2066703419 hasConceptScore W2066703419C2779980429 @default.
- W2066703419 hasConceptScore W2066703419C2781285907 @default.
- W2066703419 hasConceptScore W2066703419C55493867 @default.
- W2066703419 hasConceptScore W2066703419C7104941 @default.
- W2066703419 hasConceptScore W2066703419C71924100 @default.