FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066703560> ?p ?o ?g. }

• W2066703560 abstract "Inflammatory bowel disease (IBD) is a multifactorial disease with a significant genetic background. Evidence is accumulating that molecules such as CD14, which interact with luminal bacterial constituents, are involved in the pathogenesis. It has recently been shown that the T allele of the 5'-flanking region of the CD14 gene at position -159 is related to high expression of CD14. In further exploring the genetic background of IBD, we investigated this novel polymorphism of CD14 gene in patients with ulcerative colitis or Crohn disease.DNA was obtained from 101 patients with ulcerative colitis, 82 with Crohn disease and 123 healthy controls. All were typed for the promoter polymorphism of the CD14 gene at position -159 by restriction fragment length polymorphism analysis. Serum samples were obtained from 105 healthy controls and serum sCD14 levels were measured.T allele frequencies were 57.4%, 48.2% and 44.7% in ulcerative colitis, Crohn disease and healthy controls, respectively. The T allele and T/T genotype frequencies were significantly higher in ulcerative colitis patients than in healthy controls (P = 0.0074, OR = 1.67, 95% CI = 1.15-2.42, P = 0.022, OR= 1.96 95% CI: 1.10-3.48, respectively). The sCD14 level was significantly higher in TT genotype populations than CC (P = 0.0205).The promoter polymorphism of the CD14 gene at -159T plays a significant role in regulating the CD14 expression and is positively associated with ulcerative colitis, and this polymorphism may confer a genetic predisposition to ulcerative colitis. The results also support the concept that bacterial constituents may be involved in the pathogenesis of ulcerative colitis." @default.
• W2066703560 created "2016-06-24" @default.
• W2066703560 creator A5008770536 @default.
• W2066703560 creator A5014200580 @default.
• W2066703560 creator A5029930183 @default.
• W2066703560 creator A5034905709 @default.
• W2066703560 creator A5043020113 @default.
• W2066703560 creator A5068947717 @default.
• W2066703560 creator A5088772727 @default.
• W2066703560 date "2002-01-01" @default.
• W2066703560 modified "2023-09-30" @default.
• W2066703560 title "Ulcerative Colitis is Associated with a Promoter Polymorphism of Lipopolysaccharide Receptor Gene, CD14" @default.
• W2066703560 cites W1488327245 @default.
• W2066703560 cites W1508778944 @default.
• W2066703560 cites W1520365933 @default.
• W2066703560 cites W1540456190 @default.
• W2066703560 cites W1583820135 @default.
• W2066703560 cites W1601365107 @default.
• W2066703560 cites W1666992496 @default.
• W2066703560 cites W1859734622 @default.
• W2066703560 cites W1881367260 @default.
• W2066703560 cites W1969433064 @default.
• W2066703560 cites W1970157987 @default.
• W2066703560 cites W1972628791 @default.
• W2066703560 cites W1982345842 @default.
• W2066703560 cites W1992650609 @default.
• W2066703560 cites W2006660114 @default.
• W2066703560 cites W2011676390 @default.
• W2066703560 cites W2015903788 @default.
• W2066703560 cites W2018840055 @default.
• W2066703560 cites W2025959825 @default.
• W2066703560 cites W2043566053 @default.
• W2066703560 cites W2044994496 @default.
• W2066703560 cites W2052330087 @default.
• W2066703560 cites W2067394045 @default.
• W2066703560 cites W2070111160 @default.
• W2066703560 cites W2071196984 @default.
• W2066703560 cites W2071899562 @default.
• W2066703560 cites W2091294174 @default.
• W2066703560 cites W2103336744 @default.
• W2066703560 cites W2112087313 @default.
• W2066703560 cites W2122276925 @default.
• W2066703560 cites W2138101343 @default.
• W2066703560 cites W2139972156 @default.
• W2066703560 cites W2140411489 @default.
• W2066703560 cites W2142097475 @default.
• W2066703560 cites W2142252231 @default.
• W2066703560 cites W2163356014 @default.
• W2066703560 cites W2171613149 @default.
• W2066703560 cites W2172043071 @default.
• W2066703560 cites W2187213384 @default.
• W2066703560 cites W2337711722 @default.
• W2066703560 cites W2343547461 @default.
• W2066703560 doi "https://doi.org/10.1080/00365520212504" @default.
• W2066703560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12126249" @default.
• W2066703560 hasPublicationYear "2002" @default.
• W2066703560 type Work @default.
• W2066703560 sameAs 2066703560 @default.
• W2066703560 citedByCount "76" @default.
• W2066703560 countsByYear W20667035602012 @default.
• W2066703560 countsByYear W20667035602013 @default.
• W2066703560 countsByYear W20667035602014 @default.
• W2066703560 countsByYear W20667035602015 @default.
• W2066703560 countsByYear W20667035602016 @default.
• W2066703560 countsByYear W20667035602019 @default.
• W2066703560 countsByYear W20667035602021 @default.
• W2066703560 countsByYear W20667035602022 @default.
• W2066703560 countsByYear W20667035602023 @default.
• W2066703560 crossrefType "journal-article" @default.
• W2066703560 hasAuthorship W2066703560A5008770536 @default.
• W2066703560 hasAuthorship W2066703560A5014200580 @default.
• W2066703560 hasAuthorship W2066703560A5029930183 @default.
• W2066703560 hasAuthorship W2066703560A5034905709 @default.
• W2066703560 hasAuthorship W2066703560A5043020113 @default.
• W2066703560 hasAuthorship W2066703560A5068947717 @default.
• W2066703560 hasAuthorship W2066703560A5088772727 @default.
• W2066703560 hasConcept C104317684 @default.
• W2066703560 hasConcept C126322002 @default.
• W2066703560 hasConcept C135763542 @default.
• W2066703560 hasConcept C149737253 @default.
• W2066703560 hasConcept C168007829 @default.
• W2066703560 hasConcept C180754005 @default.
• W2066703560 hasConcept C203014093 @default.
• W2066703560 hasConcept C2775862500 @default.
• W2066703560 hasConcept C2778260677 @default.
• W2066703560 hasConcept C2778513237 @default.
• W2066703560 hasConcept C2779134260 @default.
• W2066703560 hasConcept C2779280984 @default.
• W2066703560 hasConcept C2780479503 @default.
• W2066703560 hasConcept C2780942790 @default.
• W2066703560 hasConcept C37463918 @default.
• W2066703560 hasConcept C54355233 @default.
• W2066703560 hasConcept C71924100 @default.
• W2066703560 hasConcept C76252995 @default.
• W2066703560 hasConcept C86803240 @default.
• W2066703560 hasConcept C8891405 @default.
• W2066703560 hasConceptScore W2066703560C104317684 @default.
• W2066703560 hasConceptScore W2066703560C126322002 @default.
• W2066703560 hasConceptScore W2066703560C135763542 @default.
• W2066703560 hasConceptScore W2066703560C149737253 @default.

• next