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- W2066704998 abstract "Introduction: Gemcitabine (G), vinorelbine (V) and their combination (GV) have shown to be useful in patients with non-small cell lung cancer (NSCLC). The purpose of this study is to confirm the activity of GV administration and to identify prognostic factors related with the clinical outcome. Methods: A retrospective analysis was carried out in relation to 144 patients with NSCL treated between October 1996 and April 2005 with G (1000-1250 mg/m 2 ) + V (25-30 mg/m 2 ) both administered on days 1 and 8 every three weeks. Results: Treatment was well tolerated, grade 3-4 neutropenia being registered as the worse toxic effect in 18% cases, including 7% of neutropenic fever. The objective response rate was 36.8% (95% CI: 28.9-44.7) and the median progression free survival and overall survival rates were 21 (18-25) and 33 (26-40) weeks respectively. In multivariate analysis only the histology of adenocarcinoma (HR 3; p<0.001), less than two metastatic sites (HR 1.7; p<0.02) and Karnofsky index (KI) above 70% (HR 1.5; p<0.02) showed a significant association with longer survival. Conclusion: The GV combination therapy is well tolerated and active in patients with advanced NSCLC. The histology of adenocarcinoma, less than two metastatic sites and KI above 70% were identified as independent variables related with longer survival." @default.
- W2066704998 created "2016-06-24" @default.
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- W2066704998 date "2007-01-01" @default.
- W2066704998 modified "2023-09-27" @default.
- W2066704998 title "Estudio retrospectivo en pacientes con diagnóstico de carcinoma de pulmón no microcítico estadio avanzado tratados con la combinación gemcitabina y vinorelbina: valoración de la eficacia terapéutica y factores pronósticos" @default.
- W2066704998 doi "https://doi.org/10.4321/s0378-48352007000200003" @default.
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