FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066705764> ?p ?o ?g. }

• W2066705764 endingPage "1378" @default.
• W2066705764 startingPage "1373" @default.
• W2066705764 abstract "To evaluate the contribution of bone marrow (BM) cells to treat neurological disorders, we examined the effectiveness of BM cells expressing the homeobox B4 (HoxB4) gene to cure mice with metachromatic leukodystrophy (MLD) through transplantation. Increased number of donor cells was observed in brains of the MLD mice transplanted with HoxB4-transduced BM cells (B4MLD) in contrast to those transplanted with control green fluorescent protein (GFP)-transduced BM cells (MIGMLD). Immunohistochemical staining showed that most of the GFP(+) cells were Iba1(+) microglia. In addition, O4(+) oligodendrocytes were identified only in the B4MLD brains but not in the MIGMLD brain. Alcian blue staining showed that accumulation of sulfatide was dramatically reduced in brain tissue from B4MLD mice, and there was a corresponding improvement in the animals' ability to walk a balance beam 8 months after transplantation. Thus transplantation of BM cells overexpressing HoxB4 appears to effectively prevent the progression of MLD in this mouse model. These findings support the idea that hematopoietic stem cells (HSCs) transduced with a HoxB4 expression vector could be the useful carriers of therapeutic proteins into the brain for regeneration of oligodendrocytes to treat such demyelinating disorders as MLD, Krabbe disease, and multiple sclerosis." @default.
• W2066705764 created "2016-06-24" @default.
• W2066705764 creator A5023330443 @default.
• W2066705764 creator A5065226133 @default.
• W2066705764 creator A5070342797 @default.
• W2066705764 creator A5090170231 @default.
• W2066705764 date "2010-07-01" @default.
• W2066705764 modified "2023-10-02" @default.
• W2066705764 title "Successful Treatment of Metachromatic Leukodystrophy Using Bone Marrow Transplantation of HoxB4 Overexpressing Cells" @default.
• W2066705764 cites W1548436366 @default.
• W2066705764 cites W1605824081 @default.
• W2066705764 cites W1966394929 @default.
• W2066705764 cites W2000156766 @default.
• W2066705764 cites W2000172237 @default.
• W2066705764 cites W2016140784 @default.
• W2066705764 cites W2018827685 @default.
• W2066705764 cites W2021550815 @default.
• W2066705764 cites W2044809815 @default.
• W2066705764 cites W2049941883 @default.
• W2066705764 cites W2051526728 @default.
• W2066705764 cites W2061294615 @default.
• W2066705764 cites W2065111968 @default.
• W2066705764 cites W2065606463 @default.
• W2066705764 cites W2069665168 @default.
• W2066705764 cites W2075520527 @default.
• W2066705764 cites W2083915486 @default.
• W2066705764 cites W2088438660 @default.
• W2066705764 cites W2095017414 @default.
• W2066705764 cites W2095297122 @default.
• W2066705764 cites W2107522917 @default.
• W2066705764 cites W2113725576 @default.
• W2066705764 cites W2118765054 @default.
• W2066705764 cites W2120584824 @default.
• W2066705764 cites W2155168377 @default.
• W2066705764 cites W2161640023 @default.
• W2066705764 cites W2167732166 @default.
• W2066705764 cites W2168526937 @default.
• W2066705764 cites W2173676508 @default.
• W2066705764 cites W2318360825 @default.
• W2066705764 cites W2325972222 @default.
• W2066705764 cites W2406608326 @default.
• W2066705764 cites W4242443907 @default.
• W2066705764 cites W4248112184 @default.
• W2066705764 doi "https://doi.org/10.1038/mt.2010.74" @default.
• W2066705764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2911255" @default.
• W2066705764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20424597" @default.
• W2066705764 hasPublicationYear "2010" @default.
• W2066705764 type Work @default.
• W2066705764 sameAs 2066705764 @default.
• W2066705764 citedByCount "21" @default.
• W2066705764 countsByYear W20667057642012 @default.
• W2066705764 countsByYear W20667057642013 @default.
• W2066705764 countsByYear W20667057642014 @default.
• W2066705764 countsByYear W20667057642015 @default.
• W2066705764 countsByYear W20667057642016 @default.
• W2066705764 countsByYear W20667057642017 @default.
• W2066705764 countsByYear W20667057642018 @default.
• W2066705764 countsByYear W20667057642019 @default.
• W2066705764 countsByYear W20667057642021 @default.
• W2066705764 countsByYear W20667057642023 @default.
• W2066705764 crossrefType "journal-article" @default.
• W2066705764 hasAuthorship W2066705764A5023330443 @default.
• W2066705764 hasAuthorship W2066705764A5065226133 @default.
• W2066705764 hasAuthorship W2066705764A5070342797 @default.
• W2066705764 hasAuthorship W2066705764A5090170231 @default.
• W2066705764 hasBestOaLocation W20667057641 @default.
• W2066705764 hasConcept C104317684 @default.
• W2066705764 hasConcept C111599444 @default.
• W2066705764 hasConcept C126322002 @default.
• W2066705764 hasConcept C142724271 @default.
• W2066705764 hasConcept C203014093 @default.
• W2066705764 hasConcept C2776326100 @default.
• W2066705764 hasConcept C2776914184 @default.
• W2066705764 hasConcept C2779830541 @default.
• W2066705764 hasConcept C2780007613 @default.
• W2066705764 hasConcept C28328180 @default.
• W2066705764 hasConcept C2911091166 @default.
• W2066705764 hasConcept C502942594 @default.
• W2066705764 hasConcept C55493867 @default.
• W2066705764 hasConcept C71924100 @default.
• W2066705764 hasConcept C86803240 @default.
• W2066705764 hasConcept C95444343 @default.
• W2066705764 hasConceptScore W2066705764C104317684 @default.
• W2066705764 hasConceptScore W2066705764C111599444 @default.
• W2066705764 hasConceptScore W2066705764C126322002 @default.
• W2066705764 hasConceptScore W2066705764C142724271 @default.
• W2066705764 hasConceptScore W2066705764C203014093 @default.
• W2066705764 hasConceptScore W2066705764C2776326100 @default.
• W2066705764 hasConceptScore W2066705764C2776914184 @default.
• W2066705764 hasConceptScore W2066705764C2779830541 @default.
• W2066705764 hasConceptScore W2066705764C2780007613 @default.
• W2066705764 hasConceptScore W2066705764C28328180 @default.
• W2066705764 hasConceptScore W2066705764C2911091166 @default.
• W2066705764 hasConceptScore W2066705764C502942594 @default.
• W2066705764 hasConceptScore W2066705764C55493867 @default.
• W2066705764 hasConceptScore W2066705764C71924100 @default.
• W2066705764 hasConceptScore W2066705764C86803240 @default.
• W2066705764 hasConceptScore W2066705764C95444343 @default.

• next