Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066706580> ?p ?o ?g. }
- W2066706580 endingPage "372" @default.
- W2066706580 startingPage "363" @default.
- W2066706580 abstract "Abstract Analysis of Chlamydomonas axonemes revealed that the protein phosphatase, PP2A, is localized to the outer doublet microtubules and is implicated in regulation of dynein‐driven motility. We tested the hypothesis that PP2A is localized to the axoneme by a specialized, highly conserved 55‐kDa B‐type subunit identified in the Chlamydomonas flagellar proteome. The B‐subunit gene is defective in the motility mutant pf4. Consistent with our hypothesis, both the B‐ and C‐ subunits of PP2A fail to assemble in pf4 axonemes, while the dyneins and other axonemal structures are fully assembled in pf4 axonemes. Two pf4 intragenic revertants were recovered that restore PP2A to the axonemes and re‐establish nearly wild‐type motility. The revertants confirmed that the slow‐swimming Pf4 phenotype is a result of the defective PP2A B‐subunit. These results demonstrate that the axonemal B‐subunit is, in part, an anchor protein required for PP2A localization and that PP2A is required for normal ciliary motility. © 2011 Wiley‐Liss, Inc." @default.
- W2066706580 created "2016-06-24" @default.
- W2066706580 creator A5018555385 @default.
- W2066706580 creator A5030277168 @default.
- W2066706580 creator A5030765362 @default.
- W2066706580 creator A5034239702 @default.
- W2066706580 creator A5062637696 @default.
- W2066706580 creator A5076154910 @default.
- W2066706580 creator A5076609775 @default.
- W2066706580 creator A5080795341 @default.
- W2066706580 date "2011-07-01" @default.
- W2066706580 modified "2023-10-18" @default.
- W2066706580 title "An axonemal PP2A B-subunit is required for PP2A localization and flagellar motility" @default.
- W2066706580 cites W1507284849 @default.
- W2066706580 cites W1528602163 @default.
- W2066706580 cites W161301760 @default.
- W2066706580 cites W1971335607 @default.
- W2066706580 cites W1974923921 @default.
- W2066706580 cites W1979490039 @default.
- W2066706580 cites W1981117368 @default.
- W2066706580 cites W1986394439 @default.
- W2066706580 cites W1987528621 @default.
- W2066706580 cites W1987633674 @default.
- W2066706580 cites W1987943641 @default.
- W2066706580 cites W1988378261 @default.
- W2066706580 cites W1989813669 @default.
- W2066706580 cites W1990990805 @default.
- W2066706580 cites W1996665120 @default.
- W2066706580 cites W1998085864 @default.
- W2066706580 cites W1998312642 @default.
- W2066706580 cites W1998328448 @default.
- W2066706580 cites W2001534267 @default.
- W2066706580 cites W2002614726 @default.
- W2066706580 cites W2013720405 @default.
- W2066706580 cites W2016504972 @default.
- W2066706580 cites W2016617586 @default.
- W2066706580 cites W2016959238 @default.
- W2066706580 cites W2019354483 @default.
- W2066706580 cites W2028746615 @default.
- W2066706580 cites W2029455569 @default.
- W2066706580 cites W2032542172 @default.
- W2066706580 cites W2032866323 @default.
- W2066706580 cites W2033925514 @default.
- W2066706580 cites W2042268974 @default.
- W2066706580 cites W2043924172 @default.
- W2066706580 cites W2048159541 @default.
- W2066706580 cites W2060770087 @default.
- W2066706580 cites W2063043817 @default.
- W2066706580 cites W2063175090 @default.
- W2066706580 cites W2070544692 @default.
- W2066706580 cites W2072170340 @default.
- W2066706580 cites W2072618554 @default.
- W2066706580 cites W2077266233 @default.
- W2066706580 cites W2081375316 @default.
- W2066706580 cites W2082558596 @default.
- W2066706580 cites W2089665250 @default.
- W2066706580 cites W2093543973 @default.
- W2066706580 cites W2101266961 @default.
- W2066706580 cites W2103515352 @default.
- W2066706580 cites W2109516793 @default.
- W2066706580 cites W2109985607 @default.
- W2066706580 cites W2111467807 @default.
- W2066706580 cites W2116038522 @default.
- W2066706580 cites W2133498336 @default.
- W2066706580 cites W2138222813 @default.
- W2066706580 cites W2140115740 @default.
- W2066706580 cites W2140534241 @default.
- W2066706580 cites W2142901054 @default.
- W2066706580 cites W2147191468 @default.
- W2066706580 cites W2147902314 @default.
- W2066706580 cites W2148655168 @default.
- W2066706580 cites W2150028083 @default.
- W2066706580 cites W2150541721 @default.
- W2066706580 cites W2152072269 @default.
- W2066706580 cites W2155022688 @default.
- W2066706580 cites W2155783111 @default.
- W2066706580 cites W2156012113 @default.
- W2066706580 cites W2157067561 @default.
- W2066706580 cites W2159638118 @default.
- W2066706580 cites W2165421630 @default.
- W2066706580 cites W2166238636 @default.
- W2066706580 cites W2166977115 @default.
- W2066706580 cites W2167064723 @default.
- W2066706580 cites W2168056473 @default.
- W2066706580 cites W2169403720 @default.
- W2066706580 cites W37654044 @default.
- W2066706580 doi "https://doi.org/10.1002/cm.20519" @default.
- W2066706580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3152255" @default.
- W2066706580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21692192" @default.
- W2066706580 hasPublicationYear "2011" @default.
- W2066706580 type Work @default.
- W2066706580 sameAs 2066706580 @default.
- W2066706580 citedByCount "20" @default.
- W2066706580 countsByYear W20667065802012 @default.
- W2066706580 countsByYear W20667065802013 @default.
- W2066706580 countsByYear W20667065802015 @default.
- W2066706580 countsByYear W20667065802017 @default.
- W2066706580 countsByYear W20667065802018 @default.