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• W2066708216 startingPage "5950" @default.
• W2066708216 abstract "There is an urgent need for the development of new drugs for the treatment of neglected tropical diseases such as human African trypanosomiasis, Chagas disease and leishmaniasis. Azasterols, have been shown to have activity against the parasites which cause these diseases. In this paper we report synthesis of new azasterols and subsequent analysis of the SAR. The chemistry focused on variations in the ester at the 3β-position of the sterol and the position of the nitrogen in the side chain. The data allowed us to derive preliminary pharmacophore models for the activity of the azasterols against the parasites which cause these diseases." @default.
• W2066708216 created "2016-06-24" @default.
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• W2066708216 date "2009-08-01" @default.
• W2066708216 modified "2023-10-16" @default.
• W2066708216 title "SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents" @default.
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• W2066708216 doi "https://doi.org/10.1016/j.bmc.2009.06.062" @default.
• W2066708216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19620005" @default.
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