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- W2066708675 abstract "The effect of polysorbate 80 on the rectal absorption of carbamazepine from a fatty suppository was investigated in the rabbit. Each animal received successively (with a wash-out of 1 week between every administration) two oral capsules of 100 mg, a suppository of carbamazepine 200 mg without surfactant, and a suppository of carbamazepine 200 mg including 2% polysorbate 80. After oral administration, the following values were obtained: Cmax 43 ± 17 μmol/l; Tmax, 5.1 ± 2.3 h; AUC, 391 ± 204 μmol h l−1. Subsequent to rectal administration of a suppository without polysorbate 80, the corresponding values were: Cmax, 28 ± 2.9 μmol/l; Tmax, 2.8 ± 1.3 h; AUC, 203 ± 29 μmol h l−1. The inclusion of polysorbate 80 resulted in a Cmax of 26 ± 6.2 μmol/l at 1.7 ± 0.5 h. The AUC value amounted to 242 ± 66 μmol h l−1. In the rabbit, rectal administration of carbamazepine from a suppository is more regular than oral absorption from capsules. Polysorbate 80 could enhance the rate and reproducibility of rectal absorption of carbamazepine from a fatty suppository: the serum concentration at 45 min amounted to 20.9 ± 3.8 μmol/l for the suppository containing polysorbate 80 vs 14.6 ± 5.9 μmol/l for that without." @default.
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- W2066708675 date "1992-04-01" @default.
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- W2066708675 title "Effects of polysorbate 80 on the pharmacokinetics of a carbamazepine suppository in the rabbit" @default.
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- W2066708675 doi "https://doi.org/10.1016/0378-5173(92)90073-b" @default.
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