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- W2066709745 abstract "Frozen sections of 52 breast carcinomas were examined for the presence and nature of a leukocytic infiltrate. The number of common leukocyte (T200-) antigen-bearing cells was remarkably high in the stromal compartment of the carcinomas, whereas the tumor foci themselves were usually infiltrated only sparsely. Approximately 80% of these T200+ stromal cells carried the myelomonocyte lineage-associated antigens M-M522 and 63D3 and exhibited non-specific esterase activity. More than 2/3 of the stromal monocytic cells expressed the T4 antigen as verified by monoclonal antibodies (MAbs) directed against different T4-associated epitopes. A T-cell analysis showed that T4+ cells clearly outweighed the total number of T cells as defined by anti-T3 and anti-TII antibodies. In addition, a correlation became apparent between the HLA-DR phenotype and the T lymphocyte content of tumor cell areas in the sense that densely infiltrated tumor areas were invariably HLA-DR+." @default.
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- W2066709745 date "1985-02-15" @default.
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- W2066709745 title "Infiltrating mononuclear cells in human breast carcinoma: Predominance of T4+ monocytic cells in the tumor stroma" @default.
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- W2066709745 doi "https://doi.org/10.1002/ijc.2910350210" @default.
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