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- W2066716632 abstract "Nuclear factor kappaB (NF-kappaB) is a ubiquitous transcription factor activated by various stimuli implicated in heart failure progression. However, its activation in heart failure has not been well defined yet. Therefore, we investigated activation of NF-kappaB after myocardial infarction. For the first time, we performed serial, non-invasive in vivo molecular imaging of transcription factor activation in the heart. We used mice expressing a luciferase reporter whose transcription is dependent upon NF-kappaB activation for up to 8 weeks after myocardial infarction. There was a significant increase of NF-kappaB activity with a maximum at day 3 after myocardial infarction when compared to sham controls. Thus, in vivo measurement of the activation of NF-kappaB is feasible. NF-kappaB activity might play an important role for the remodeling process." @default.
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- W2066716632 date "2006-04-01" @default.
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- W2066716632 title "Caught in the act: In vivo molecular imaging of the transcription factor NF-κB after myocardial infarction" @default.
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- W2066716632 doi "https://doi.org/10.1016/j.bbrc.2006.02.024" @default.
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