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- W2066717863 abstract "CABG thrombosis is a common disorder without adequate therapy. To assess the effects of selective laser thrombolysis (LT) in CABG, aortocoronary bypasses were created and completely thrombosed in nine swine. Maximal thrombus removal was achieved with pulsed dye laser light (577 nm, 1 μs pulse, 3 Hz, 64 mJ/pulse) by fluid catheter for 6.7 ± 1 min. Graft flow and thrombosis were assessed by angio with global and grafted segment myocardial function measured by epicardial echo at constant load. Mean graft size: 8 mm × 6 cm. Prior to therapy, grafts had no flow (TIMIO) and complete thrombosis for 60 min. TIMI flow post LTwas 2.8 ± 0.4 (p < 0.001) with focal residual mural thrombus. 90 min post LT, graft appearance and flow were unchanged. Wall motion (WM) scored from normal (1) to dyskinetic (4). Index = total WM/14 segments. Occlusion 90 min postLT Global EF 0.49 ± 0.09 0.55 ± 0.04 NS Index 1.7 ± 0.1 1.1 ± 0.1 (p < 0.05) Grafted Region Wall Motion 4 1 (p < 0.01) %Wall Thick. - 5 31 (p < 0.01) 1) LT is able to rapidly remove large amounts of thrombus in CABG. 2) Thrombus removal by LT does not cause detectable changes in regional cardiac function. 3) High patency rates persist 90 min. post LT." @default.
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- W2066717863 date "1995-02-01" @default.
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- W2066717863 title "1001-27 Rapid Thrombolysis in Experimental Coronary Artery Bypass Grafts" @default.
- W2066717863 doi "https://doi.org/10.1016/0735-1097(95)92901-g" @default.
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