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• W2066730391 abstract "Lysosomes are thought to play a role in various aspects of heavy metal metabolism. In the present study we demonstrate for the first time the presence of a heavy metal ion transport protein in the lysosomal membrane. Uptake of radioactive silver both in highly purified lysosomal membrane vesicles and in purified intact lysosomes showed the typical kinetics of a carrier‐mediated process. This transport was stimulated by ATP hydrolysis, and showed specificity for Ag + , Cu 2+ , and Cd 2+ . All biochemical properties of this lysosomal metal ion transporter could classify it as a heavy metal transporting P‐type ATPase. Long Evans Cinnamon (LEC) rats, an animal model for the copper transport disorder Wilson disease, showed normal lysosomal silver transport." @default.
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• W2066730391 date "1998-10-02" @default.
• W2066730391 modified "2023-09-25" @default.
• W2066730391 title "Characterization of a heavy metal ion transporter in the lysosomal membrane" @default.
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• W2066730391 doi "https://doi.org/10.1016/s0014-5793(98)01133-8" @default.
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