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- W2066730576 abstract "Les perturbations de la coagulation sont fréquemment observées chez les patients atteints de COVID-19 ainsi que les événements cliniques thrombotiques. Ces évènements augmentent le risque de décès au cours de la maladie. Parmi les évènements biologiques, on observe une augmentation des D-Dimères (> 3 μg/L), du fibrinogène (> 8 g/L) et une thrombopénie qui caractérisent le syndrome et sont associées à un mauvais pronostic. Ces marqueurs devraient être surveillés régulièrement au cours de l’hospitalisation des patients en réanimation. Le diagnostic d’embolie pulmonaire peut être difficile dans le contexte mais doit être évoqué en cas d’aggravation inexpliquée de l’hypoxémie ou d’insuffisance cardiaque droite. Le risque thromboembolique doit être stratifié pour adapter la thrombo-prophylaxie en prenant compte la fonction rénale et le surpoids des patients.Coagulation disorders are commonly reported in patients suffering from COVID-19 pneumonia. These are associated to an increase incidence of thrombotic disorders associated with an increase mortality rate. D-Dimers concentrations > 3 μg/L, fibrinogen > 8 g/L and decreased platelets count are associated with an increased thrombotic risk. These biological markers have to be closely monitored during ICU stay. The diagnosis of pulmonary embolism could be difficult in this setting. However, it has to be evoked in case of worsening hypoxemia unexplained by other reason and/or right ventricular failure. The thrombotic risk can be scored to adapt the thromboprophylactic treatment, impaired renal function and overweight making it even more difficult." @default.
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- W2066730576 date "2012-01-01" @default.
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- W2066730576 title "Valeur pronostique de la réponse histologique complète à la chimiothérapie préopératoire dans le cancer bronchique non à petites cellules (CBNPC) de stade précoce : analyse combinée de deux essais randomisés" @default.
- W2066730576 doi "https://doi.org/10.1016/j.rmr.2011.10.049" @default.
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