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- W2066730962 abstract "Inorganic phosphate (Pi) induced swelling of heart mitochondria and resulted in an inhibition and a partial uncoupling of oxidative phosphorylation in an assay medium that contained 150 mM KCl and 1 mM pyruvate at 37°C. The swelling effect of Pi was partially inhibited and the uncoupling and inhibition of oxidative phosphorylation were completely prevented by ruthenium red (RR) but not by EGTA. The RR-insensitive swelling, on the other hand, was inhibited by rotenone, N-ethylmaleimide and 2,4-dinitrophenol but not by oligomycin. It is suggested that the Pi-induced swelling of mitochondria has two components. One component is insensitive to RR and related to the respiration-dependent uptake of potassium phosphate which by itself does not cause damage to oxidative phosphorylation. The other component of the swelling is RR- sensitive, may involve intramitochondrial calcium and results in inhibition and partial uncoupling of oxidative phosphorylation. Neither component, however, is inhibited by EGTA." @default.
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- W2066730962 title "Phosphate induced swelling, inhibition and partial uncoupling of oxidative phosphorylation in heart mitochondria in the absence of external calcium and in the presence of EGTA" @default.
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- W2066730962 doi "https://doi.org/10.1016/s0006-291x(81)80059-9" @default.
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