Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066734010> ?p ?o ?g. }
- W2066734010 endingPage "58" @default.
- W2066734010 startingPage "45" @default.
- W2066734010 abstract "Parkinson's disease is characterized by neuronal death in the substantia nigra and the presence of intracellular inclusions of α-synuclein in the Lewy bodies. Several lines of data support a role for iron in Parkinson's disease: iron is present in Lewy bodies, iron accumulates in the dopaminergic neurons in the substantia nigra, and Parkinson's disease is correlated with polymorphisms of several genes implicated in iron metabolism. Furthermore, iron can compromise the solubility of α-synuclein through direct interaction and can induce neurotoxicity in vitro. Here, we investigate the possible neuroprotective effect of the iron chelator deferoxamine in vivo to elucidate whether iron chelation can provide meaningful therapy for Parkinson's disease. Hence, we used a Parkinson's disease animal model based on unilateral injection of a recombinant adeno-associated viral vector encoding α-synuclein in the rat midbrain. Rats were treated with a novel deferoxamine delivery approach: 6 mg of the compound was administered intranasally three times a week for 3 or 7 weeks. The behavior of the animals and histopathological changes in the brain were analyzed. Our data show that although intranasal administration of deferoxamine in rats did not protect them from dopaminergic cell death, it did decrease the number of the pathological α-synuclein formations at the terminal level. In addition, this treatment resulted in changes in the immune response and an overall partial improvement in motor behavior. Taken together, our data show that in vivo iron chelation can modulate α-synuclein-induced pathology in the central nervous system. Our data suggest that chronic administration of intranasal deferoxamine may be a valid approach to limiting the mishandling of α-synuclein in the central nervous system observed in Parkinson's disease and slowing disease progression." @default.
- W2066734010 created "2016-06-24" @default.
- W2066734010 creator A5007873613 @default.
- W2066734010 creator A5019698136 @default.
- W2066734010 creator A5060525564 @default.
- W2066734010 creator A5063166587 @default.
- W2066734010 creator A5081650277 @default.
- W2066734010 date "2013-09-01" @default.
- W2066734010 modified "2023-10-14" @default.
- W2066734010 title "Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model" @default.
- W2066734010 cites W1527671059 @default.
- W2066734010 cites W1546232808 @default.
- W2066734010 cites W1963945544 @default.
- W2066734010 cites W1964271667 @default.
- W2066734010 cites W1966087329 @default.
- W2066734010 cites W1967922486 @default.
- W2066734010 cites W1968478370 @default.
- W2066734010 cites W1969314995 @default.
- W2066734010 cites W1969609724 @default.
- W2066734010 cites W1972715091 @default.
- W2066734010 cites W1972931472 @default.
- W2066734010 cites W1973264847 @default.
- W2066734010 cites W1974924674 @default.
- W2066734010 cites W1977554540 @default.
- W2066734010 cites W1977846417 @default.
- W2066734010 cites W1979243660 @default.
- W2066734010 cites W1979480763 @default.
- W2066734010 cites W1986740107 @default.
- W2066734010 cites W1989277130 @default.
- W2066734010 cites W1989522802 @default.
- W2066734010 cites W1995392551 @default.
- W2066734010 cites W1997994333 @default.
- W2066734010 cites W1998241928 @default.
- W2066734010 cites W2003456064 @default.
- W2066734010 cites W2004280801 @default.
- W2066734010 cites W2007208756 @default.
- W2066734010 cites W2010395737 @default.
- W2066734010 cites W2012787010 @default.
- W2066734010 cites W2015784694 @default.
- W2066734010 cites W2017268270 @default.
- W2066734010 cites W2018974184 @default.
- W2066734010 cites W2026455995 @default.
- W2066734010 cites W2028250171 @default.
- W2066734010 cites W2029682595 @default.
- W2066734010 cites W2036740787 @default.
- W2066734010 cites W2038636807 @default.
- W2066734010 cites W2043990301 @default.
- W2066734010 cites W2046014998 @default.
- W2066734010 cites W2048008983 @default.
- W2066734010 cites W2049366603 @default.
- W2066734010 cites W2051159468 @default.
- W2066734010 cites W2052011437 @default.
- W2066734010 cites W2054558607 @default.
- W2066734010 cites W2056143205 @default.
- W2066734010 cites W2057770297 @default.
- W2066734010 cites W2073806180 @default.
- W2066734010 cites W2082895331 @default.
- W2066734010 cites W2084272059 @default.
- W2066734010 cites W2085490428 @default.
- W2066734010 cites W2085842761 @default.
- W2066734010 cites W2086857730 @default.
- W2066734010 cites W2093131325 @default.
- W2066734010 cites W2095378987 @default.
- W2066734010 cites W2100919899 @default.
- W2066734010 cites W2104281624 @default.
- W2066734010 cites W2106319740 @default.
- W2066734010 cites W2107405263 @default.
- W2066734010 cites W2111279074 @default.
- W2066734010 cites W2116766274 @default.
- W2066734010 cites W2121981334 @default.
- W2066734010 cites W2130312571 @default.
- W2066734010 cites W2132652745 @default.
- W2066734010 cites W2135124264 @default.
- W2066734010 cites W2144258071 @default.
- W2066734010 cites W2145213346 @default.
- W2066734010 cites W2148726772 @default.
- W2066734010 cites W2156118851 @default.
- W2066734010 cites W2159277875 @default.
- W2066734010 cites W2159329523 @default.
- W2066734010 cites W2166496419 @default.
- W2066734010 cites W2166789153 @default.
- W2066734010 cites W2168620413 @default.
- W2066734010 cites W2337170605 @default.
- W2066734010 cites W4246230178 @default.
- W2066734010 cites W4296930794 @default.
- W2066734010 doi "https://doi.org/10.1016/j.expneurol.2013.03.017" @default.
- W2066734010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23531432" @default.
- W2066734010 hasPublicationYear "2013" @default.
- W2066734010 type Work @default.
- W2066734010 sameAs 2066734010 @default.
- W2066734010 citedByCount "50" @default.
- W2066734010 countsByYear W20667340102013 @default.
- W2066734010 countsByYear W20667340102014 @default.
- W2066734010 countsByYear W20667340102015 @default.
- W2066734010 countsByYear W20667340102016 @default.
- W2066734010 countsByYear W20667340102017 @default.
- W2066734010 countsByYear W20667340102018 @default.
- W2066734010 countsByYear W20667340102019 @default.