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- W2066742079 abstract "<h3>Objective:</h3> The aim of this study was to investigate whether cognitively preserved monozygotic or dizygotic cotwins of persons with Alzheimer disease (AD) exhibit increased brain amyloid accumulation. <h3>Methods:</h3> We performed a cross-sectional carbon-11 labeled 2-(4′-methylaminophenyl)-6-hydroxybenzothiazole (<sup>11</sup>C)–Pittsburgh compound B (PiB) PET study on 9 monozygotic and 8 dizygotic twin pairs discordant for cognitive impairment as well as on 9 healthy elderly control subjects. <sup>11</sup>C-PiB uptake was analyzed with Statistical Parametric Mapping and with region of interest analysis with the region-to-cerebellum ratio as a measure of tracer uptake. <h3>Results:</h3> Cognitively preserved monozygotic cotwins of cognitively impaired probands had increased cortical <sup>11</sup>C-PiB uptake (117%–121% of control mean) in their temporal and parietal cortices and the posterior cingulate. Cognitively preserved dizygotic subjects did not differ from the controls. Further, the cognitively preserved monozygotic subjects showed similar <sup>11</sup>C-PiB uptake patterns as their cognitively impaired cotwins. The cognitively impaired subjects (monozygotic and dizygotic individuals combined) showed typical Alzheimer-like patterns of <sup>11</sup>C-PiB uptake. <h3>Conclusions:</h3> Genetic factors appear to influence the development of Alzheimer-like β-amyloid plaque pathology. The dissociation between cognitive impairment and brain β-amyloidosis in monozygotic twins implies that there may be important environmental/acquired factors that modulate the relationship between brain amyloidosis and neurodegeneration. AD may be detectable in high-risk individuals in its presymptomatic stage with <sup>11</sup>C-PiB PET, but clinical follow-up will be needed to confirm this." @default.
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- W2066742079 date "2011-08-02" @default.
- W2066742079 modified "2023-10-17" @default.
- W2066742079 title "Early detection of Alzheimer disease: 11C-PiB PET in twins discordant for cognitive impairment" @default.
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- W2066742079 doi "https://doi.org/10.1212/wnl.0b013e318225118e" @default.
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