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- W2066745997 abstract "Thirty-five neutral steroids and bile acids have been studied for their ability to lyse rabbit erythrocytes. Hemolytic activity was found to be associated with the 5-β-H configuration. A few Δ-4,5 steroids were active, but 5-α-H compounds were inactive. Oxygenation at C-11 or the presence of an α-hydroxyl group at C-17 abolished activity. The hemolysis induced by neutral steroids was characterized by (1) sharp concentration dependence above a critical concentration; (2) marked loss of activity at 24° compared with 37°; (3) inhibition by serum; (4) prelytic loss of potassium; and (5) marked augmentation by inactive steroids, including the 3-β-OH and 5-α-H or Δ-4 compounds which inhibit bile acid-induced hemolysis. These results are compatible with the hypothesis that neutral steroids exert their pharmacologie effects, at least in part, through actions on the membranes of cells or their organelles." @default.
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- W2066745997 date "1965-04-01" @default.
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- W2066745997 title "Hemolysis and augmentation of hemolysis by neutral steroids and bile acids" @default.
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- W2066745997 doi "https://doi.org/10.1016/0006-2952(65)90226-1" @default.
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