FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066748558> ?p ?o ?g. }

• W2066748558 endingPage "1465" @default.
• W2066748558 startingPage "1454" @default.
• W2066748558 abstract "Autophagy is reported to suppress tumor proliferation, whereas deficiency of autophagy is associated with tumorigenesis. ATG4B is a deubiquitin-like protease that plays dual roles in the core machinery of autophagy; however, little is known about the role of ATG4B on autophagy and proliferation in tumor cells. In this study, we found that ATG4B knockdown induced autophagic flux and reduced CCND1 expression to inhibit G 1/S phase transition of cell cycle in colorectal cancer cell lines, indicating functional dominance of ATG4B on autophagy inhibition and tumor proliferation in cancer cells. Interestingly, based on the genetic and pharmacological ablation of autophagy, the growth arrest induced by silencing ATG4B was independent of autophagic flux. Moreover, dephosphorylation of MTOR was involved in reduced CCND1 expression and G 1/S phase transition in both cells and xenograft tumors with depletion of ATG4B. Furthermore, ATG4B expression was significantly increased in tumor cells of colorectal cancer patients compared with adjacent normal cells. The elevated expression of ATG4B was highly correlated with CCND1 expression, consistently supporting the notion that ATG4B might contribute to MTOR-CCND1 signaling for G 1/S phase transition in colorectal cancer cells. Thus, we report that ATG4B independently plays a role as a positive regulator on tumor proliferation and a negative regulator on autophagy in colorectal cancer cells. These results suggest that ATG4B is a potential biomarker and drug target for cancer therapy." @default.
• W2066748558 created "2016-06-24" @default.
• W2066748558 creator A5006345625 @default.
• W2066748558 creator A5029376078 @default.
• W2066748558 creator A5032657210 @default.
• W2066748558 creator A5032760915 @default.
• W2066748558 creator A5035471005 @default.
• W2066748558 creator A5043035095 @default.
• W2066748558 creator A5046721989 @default.
• W2066748558 creator A5049286016 @default.
• W2066748558 creator A5057832539 @default.
• W2066748558 creator A5088558005 @default.
• W2066748558 creator A5089722538 @default.
• W2066748558 creator A5090333902 @default.
• W2066748558 date "2014-06-12" @default.
• W2066748558 modified "2023-10-14" @default.
• W2066748558 title "ATG4B promotes colorectal cancer growth independent of autophagic flux" @default.
• W2066748558 cites W1493931678 @default.
• W2066748558 cites W1496026049 @default.
• W2066748558 cites W1554815317 @default.
• W2066748558 cites W1784425676 @default.
• W2066748558 cites W1964649068 @default.
• W2066748558 cites W1965814195 @default.
• W2066748558 cites W1970637701 @default.
• W2066748558 cites W1994411647 @default.
• W2066748558 cites W1994823455 @default.
• W2066748558 cites W2001943317 @default.
• W2066748558 cites W2003380425 @default.
• W2066748558 cites W2005249937 @default.
• W2066748558 cites W2009295603 @default.
• W2066748558 cites W2012040176 @default.
• W2066748558 cites W2014918593 @default.
• W2066748558 cites W2015541033 @default.
• W2066748558 cites W2016869069 @default.
• W2066748558 cites W2021447050 @default.
• W2066748558 cites W2025665129 @default.
• W2066748558 cites W2025935112 @default.
• W2066748558 cites W2034339677 @default.
• W2066748558 cites W2035542044 @default.
• W2066748558 cites W2040089067 @default.
• W2066748558 cites W2040157483 @default.
• W2066748558 cites W2044889666 @default.
• W2066748558 cites W2052581434 @default.
• W2066748558 cites W2055029337 @default.
• W2066748558 cites W2057813271 @default.
• W2066748558 cites W2065575458 @default.
• W2066748558 cites W2068153705 @default.
• W2066748558 cites W2070224555 @default.
• W2066748558 cites W2070536046 @default.
• W2066748558 cites W2071014725 @default.
• W2066748558 cites W2073963703 @default.
• W2066748558 cites W2077418979 @default.
• W2066748558 cites W2083080666 @default.
• W2066748558 cites W2085129546 @default.
• W2066748558 cites W2085442981 @default.
• W2066748558 cites W2093530916 @default.
• W2066748558 cites W2095238101 @default.
• W2066748558 cites W2108995183 @default.
• W2066748558 cites W2110546638 @default.
• W2066748558 cites W2114806766 @default.
• W2066748558 cites W2115886998 @default.
• W2066748558 cites W2115888489 @default.
• W2066748558 cites W2116836791 @default.
• W2066748558 cites W2127362646 @default.
• W2066748558 cites W2135901758 @default.
• W2066748558 cites W2136789586 @default.
• W2066748558 cites W2139830524 @default.
• W2066748558 cites W2140638448 @default.
• W2066748558 cites W2155452700 @default.
• W2066748558 cites W2158051947 @default.
• W2066748558 cites W2159018448 @default.
• W2066748558 cites W2161050915 @default.
• W2066748558 cites W2167638513 @default.
• W2066748558 doi "https://doi.org/10.4161/auto.29556" @default.
• W2066748558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4203521" @default.
• W2066748558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24991826" @default.
• W2066748558 hasPublicationYear "2014" @default.
• W2066748558 type Work @default.
• W2066748558 sameAs 2066748558 @default.
• W2066748558 citedByCount "59" @default.
• W2066748558 countsByYear W20667485582015 @default.
• W2066748558 countsByYear W20667485582016 @default.
• W2066748558 countsByYear W20667485582017 @default.
• W2066748558 countsByYear W20667485582018 @default.
• W2066748558 countsByYear W20667485582019 @default.
• W2066748558 countsByYear W20667485582020 @default.
• W2066748558 countsByYear W20667485582021 @default.
• W2066748558 countsByYear W20667485582022 @default.
• W2066748558 countsByYear W20667485582023 @default.
• W2066748558 crossrefType "journal-article" @default.
• W2066748558 hasAuthorship W2066748558A5006345625 @default.
• W2066748558 hasAuthorship W2066748558A5029376078 @default.
• W2066748558 hasAuthorship W2066748558A5032657210 @default.
• W2066748558 hasAuthorship W2066748558A5032760915 @default.
• W2066748558 hasAuthorship W2066748558A5035471005 @default.
• W2066748558 hasAuthorship W2066748558A5043035095 @default.
• W2066748558 hasAuthorship W2066748558A5046721989 @default.
• W2066748558 hasAuthorship W2066748558A5049286016 @default.

• next