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• W2066777762 endingPage "131" @default.
• W2066777762 startingPage "111" @default.
• W2066777762 abstract "Multiple myeloma (MM) is a neoplastic disease characterized by the expansion of monoclonal plasma cells that seed throughout bone marrow, causing lytic bone lesions, and introduce monoclonal immunoglobulins, hence the term monoclonal gammopathy. The incidence of monoclonal gammopathies in the healthy population is very high. It is rare in persons under 40 years of age, with incidence increasing to 7% to 8% in persons over 65 years of age.1, 136 The majority of MM patients had a prior asymptomatic gammopathy102; however, most persons with monoclonal gammopathy of undetermined significance (MGUS) will not develop MM. It is, therefore, probable that there are two distinct types of monoclonal gammopathies, benign and malignant. There is currently no test that distinguishes between benign and malignant monoclonal gammopathy. Clinically, patients with MGUS can be divided into two groups, with most requiring only routine follow-up, and the remainder requiring immediate chemotherapeutic intervention owing to evidence of overt disease progression. Helpful tests, such as measures of plasma cells in S phase,37, 64, 80 β2-microglobulin serum levels,25, 65 and IL-6 serum levels,98, 107, 109, 142 may contribute to determining a diagnosis; however, disease progression is clearly defined only after precipitous increase in monoclonal immunoglobulins or appearance of lytic bone lesions. The choice of appropriate therapy regimen remains controversial. The efficacy of melphalan and prednisone (MP), first introduced for MM more than 25 years ago,7 has been compared with several alternative regimens. They resulted equivalent to MP, but should be employed only in special cases such as renal failure, or to prevent stem cell damage.152 Recently, new high-dose chemotherapies have been shown to prolong duration of remission and survival, at least in young patients.10 This article presents criteria for diagnosing MM, prognostic factors useful for choosing therapeutic options, and standard treatment options." @default.
• W2066777762 created "2016-06-24" @default.
• W2066777762 creator A5018139001 @default.
• W2066777762 creator A5020164754 @default.
• W2066777762 date "1997-02-01" @default.
• W2066777762 modified "2023-09-27" @default.
• W2066777762 title "DIAGNOSIS, PROGNOSIS, AND STANDARD TREATMENT OF MULTIPLE MYELOMA" @default.
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