FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066778844> ?p ?o ?g. }

• W2066778844 endingPage "385" @default.
• W2066778844 startingPage "379" @default.
• W2066778844 abstract "The anterior hypothalamic preoptic area (AH/POA) was examined as a possible site of action of clonidine and other alpha noradrenergic receptor agonists which evoke motor and autonomie changes. Chronically indwelling guide cannulae were implanted stereotaxically in the diencephalon of the cat. Following post-operative recovery, a micro-injection into AH/POA was made in a volume of 1.0 μl of one of the following compounds: 5.0–50.0 μg clonidine, 5.0–50.0 μg norepinephrine, 5.0–50.0 μg phenylephrine and 5.0–50.0 μg methoxamine. The smallest dose of 5.0 μg clonidine produced a brief period of restlessness, licking, retching and emesis but a much longer-lasting mydriasis. When the dose of clonidine was raised to 20 μg, the cat became behaviorally sedated, after a latency of about 15 min, for a period of up to 1.0–2.0 hr. This was accompanied by a prolonged period of mydriais and preceded by a short interval of restlessness, licking, retching and emesis. After the highest dose of 50.0 μg clonidine was micro-injected in AH/POA, a profound impairment of motor activity, adynomia and restlessness developed within 15–20 min, persisted for 30 to 60 min and was accompanied also by mydriasis with maximal pupillary dilation lasting for up to six hr. When 5.0–50.0 μg phenylephrine or 5.0–50.0 μg norepinephrine were micro-injected at clonidine-reactive sites in AH/POA, only rarely were brief instances of restlessness, licking, retching and emesis observed; however, methoxamine at all doses tested failed to produce any visible signs of autonomie or motor disturbance. Pretreatment of clonidine-sensitive sites by micro-injection of yohimbine (5.0–10.0 μg), an alpha-2 noradrenergic antagonist, inhibited the clonidine-induced sedation and impairment of motor activity; conversely, the mixed alpha-receptor blocking drug, phentolamine, did not alter clonidine's locomotor effects. Both antagonists failed to block mydriasis in the cat, and similar pre-treatment with the antimuscarinic drug, atropine (5.0–20.0 μg), 5-hydroxytryptamine antagonist, methysergide (5.0–20.0 μg), the dopamine antagonist, chlorpromazine (5.0–20.0 μg) or the opioid antagonist, naloxone (5.0–20.0 μg), failed to attenuate the clonidine-induced mydriasis. These results suggest that clonidine-induced sedation and motor impairment in the cat are mediated by a localized alpha-2 noradrenergic receptor mechanism in the diencephalon; however, the concomitant mydriasis is apparently not subserved by alpha noradrenergic, muscarinic. serotonergic, dopaminergic and opioid receptor sub-types in this forebrain structure." @default.
• W2066778844 created "2016-06-24" @default.
• W2066778844 creator A5024744513 @default.
• W2066778844 creator A5067748815 @default.
• W2066778844 creator A5071703173 @default.
• W2066778844 date "1986-09-01" @default.
• W2066778844 modified "2023-09-23" @default.
• W2066778844 title "Dissociation of locomotor impairment from mydriasis evoked by clonidine injected into cat's rostral hypothalamus" @default.
• W2066778844 cites W1581768752 @default.
• W2066778844 cites W1965810045 @default.
• W2066778844 cites W1969635202 @default.
• W2066778844 cites W1977914280 @default.
• W2066778844 cites W1978574384 @default.
• W2066778844 cites W1979834124 @default.
• W2066778844 cites W1986384673 @default.
• W2066778844 cites W1994946404 @default.
• W2066778844 cites W1996283992 @default.
• W2066778844 cites W2002438359 @default.
• W2066778844 cites W2005736372 @default.
• W2066778844 cites W2009490000 @default.
• W2066778844 cites W2010034658 @default.
• W2066778844 cites W2011537858 @default.
• W2066778844 cites W2017672206 @default.
• W2066778844 cites W2023140990 @default.
• W2066778844 cites W2023726167 @default.
• W2066778844 cites W2025856230 @default.
• W2066778844 cites W2026812180 @default.
• W2066778844 cites W2027886306 @default.
• W2066778844 cites W2033766387 @default.
• W2066778844 cites W2038523563 @default.
• W2066778844 cites W2048107676 @default.
• W2066778844 cites W2081621943 @default.
• W2066778844 cites W2091964096 @default.
• W2066778844 cites W2100669409 @default.
• W2066778844 cites W2115464770 @default.
• W2066778844 cites W2134135587 @default.
• W2066778844 cites W2158557967 @default.
• W2066778844 cites W2315081567 @default.
• W2066778844 cites W2335416857 @default.
• W2066778844 cites W2406004732 @default.
• W2066778844 cites W2885921373 @default.
• W2066778844 cites W617440007 @default.
• W2066778844 doi "https://doi.org/10.1016/0361-9230(86)90241-8" @default.
• W2066778844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2876757" @default.
• W2066778844 hasPublicationYear "1986" @default.
• W2066778844 type Work @default.
• W2066778844 sameAs 2066778844 @default.
• W2066778844 citedByCount "7" @default.
• W2066778844 crossrefType "journal-article" @default.
• W2066778844 hasAuthorship W2066778844A5024744513 @default.
• W2066778844 hasAuthorship W2066778844A5067748815 @default.
• W2066778844 hasAuthorship W2066778844A5071703173 @default.
• W2066778844 hasConcept C126322002 @default.
• W2066778844 hasConcept C134018914 @default.
• W2066778844 hasConcept C170493617 @default.
• W2066778844 hasConcept C185592680 @default.
• W2066778844 hasConcept C2776885963 @default.
• W2066778844 hasConcept C2777676773 @default.
• W2066778844 hasConcept C2777952589 @default.
• W2066778844 hasConcept C2778399450 @default.
• W2066778844 hasConcept C2778573518 @default.
• W2066778844 hasConcept C2779109636 @default.
• W2066778844 hasConcept C2780723003 @default.
• W2066778844 hasConcept C2780852908 @default.
• W2066778844 hasConcept C42219234 @default.
• W2066778844 hasConcept C71924100 @default.
• W2066778844 hasConcept C84393581 @default.
• W2066778844 hasConceptScore W2066778844C126322002 @default.
• W2066778844 hasConceptScore W2066778844C134018914 @default.
• W2066778844 hasConceptScore W2066778844C170493617 @default.
• W2066778844 hasConceptScore W2066778844C185592680 @default.
• W2066778844 hasConceptScore W2066778844C2776885963 @default.
• W2066778844 hasConceptScore W2066778844C2777676773 @default.
• W2066778844 hasConceptScore W2066778844C2777952589 @default.
• W2066778844 hasConceptScore W2066778844C2778399450 @default.
• W2066778844 hasConceptScore W2066778844C2778573518 @default.
• W2066778844 hasConceptScore W2066778844C2779109636 @default.
• W2066778844 hasConceptScore W2066778844C2780723003 @default.
• W2066778844 hasConceptScore W2066778844C2780852908 @default.
• W2066778844 hasConceptScore W2066778844C42219234 @default.
• W2066778844 hasConceptScore W2066778844C71924100 @default.
• W2066778844 hasConceptScore W2066778844C84393581 @default.
• W2066778844 hasIssue "3" @default.
• W2066778844 hasLocation W20667788441 @default.
• W2066778844 hasLocation W20667788442 @default.
• W2066778844 hasOpenAccess W2066778844 @default.
• W2066778844 hasPrimaryLocation W20667788441 @default.
• W2066778844 hasRelatedWork W115398284 @default.
• W2066778844 hasRelatedWork W1506809873 @default.
• W2066778844 hasRelatedWork W2013457480 @default.
• W2066778844 hasRelatedWork W2023307846 @default.
• W2066778844 hasRelatedWork W2055714395 @default.
• W2066778844 hasRelatedWork W2066778844 @default.
• W2066778844 hasRelatedWork W2124902444 @default.
• W2066778844 hasRelatedWork W2133351730 @default.
• W2066778844 hasRelatedWork W2144226084 @default.
• W2066778844 hasRelatedWork W2190604364 @default.
• W2066778844 hasVolume "17" @default.

• next