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- W2066778963 abstract "Objective Bilirubin has been recognized as an important endogeneous antioxidant. Previous studies reported that bilirubin could prevent atherosclerosis. The aim of this study was to investigate if serum bilirubin concentration could be a predictor for the development of albuminuria in patients with type 2 diabetes. Materials and Methods We measured serum bilirubin in 320 consecutive patients with normoalbuminuria. We performed follow-up study to assess the development of albuminuria, mean interval of which was 3.2 ± 0.9 years. Cox proportional hazards regression was used to examine the relationship between serum bilirubin concentration and the development of albuminuria. Results During follow-up duration, 43 patients have developed albuminuria. In multivariate analysis, after adjusting for comprehensive risk factors, the risk of developing albuminuria was higher in the lowest quartile of serum bilirubin concentrations than that in the highest quartile of serum bilirubin concentrations (Hazard ratio, 5.76; 95% CI, 1.65 to 24.93). Conclusions Low serum bilirubin concentration could be a novel risk factor for the development of albuminuria in patients with type 2 diabetes." @default.
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- W2066778963 date "2014-03-01" @default.
- W2066778963 modified "2023-09-30" @default.
- W2066778963 title "Low serum bilirubin concentration is a novel risk factor for the development of albuminuria in patients with type 2 diabetes" @default.
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- W2066778963 doi "https://doi.org/10.1016/j.metabol.2013.11.011" @default.
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