FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066784616> ?p ?o ?g. }

• W2066784616 endingPage "899" @default.
• W2066784616 startingPage "893" @default.
• W2066784616 abstract "The effect of estradiol on the binding of epidermal growth factor (EGF) was investigated in a rat granulosa cell culture system. Cultured granulosa cells without estradiol possess an EGF receptor with a Kd value of 7.4 x 10(-10) M and binding sites of 1.45 x 10(3) molecules per cell. The addition of estradiol to the culture media resulted in an increase in the binding of EGF in a dose-dependent manner at concentration between 10(-9) M and 10(-7) M. Estradiol at 10(-7) M produced a 2.5-fold increase in the number of binding sites without affecting the binding affinity. An increase in the binding was observed as early as after 6 h incubation. The addition of testosterone alone had no effect on the EGF binding. However, in the presence of follicle stimulating hormone, it increased the binding dose-dependently. The stimulatory effect of testosterone was completely abolished by an aromatase inhibitor, thus suggesting that estradiol converted from testosterone could be a contributing factor in the mechanism of testosterone action. These observations imply that estradiol may play a role in regulating growth and the differentiation of granulosa cells by modulating the EGF binding." @default.
• W2066784616 created "2016-06-24" @default.
• W2066784616 creator A5036135855 @default.
• W2066784616 creator A5046918160 @default.
• W2066784616 creator A5071911822 @default.
• W2066784616 date "1990-01-01" @default.
• W2066784616 modified "2023-10-03" @default.
• W2066784616 title "Estradiol Stimulated the Binding of Epidermal Growth Factor in Cultured Rat Granulosa Cells." @default.
• W2066784616 cites W1490958709 @default.
• W2066784616 cites W1519416684 @default.
• W2066784616 cites W1554960389 @default.
• W2066784616 cites W1579836766 @default.
• W2066784616 cites W1601196993 @default.
• W2066784616 cites W1967963209 @default.
• W2066784616 cites W1989732246 @default.
• W2066784616 cites W1994056807 @default.
• W2066784616 cites W2010394496 @default.
• W2066784616 cites W2012888904 @default.
• W2066784616 cites W2022685782 @default.
• W2066784616 cites W2037812119 @default.
• W2066784616 cites W2051320760 @default.
• W2066784616 cites W2064982147 @default.
• W2066784616 cites W2074140943 @default.
• W2066784616 cites W2079198737 @default.
• W2066784616 cites W2082182989 @default.
• W2066784616 cites W2085513598 @default.
• W2066784616 cites W2105778329 @default.
• W2066784616 cites W2124974256 @default.
• W2066784616 cites W2161276384 @default.
• W2066784616 cites W2169173740 @default.
• W2066784616 doi "https://doi.org/10.1507/endocrj1954.37.893" @default.
• W2066784616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2129303" @default.
• W2066784616 hasPublicationYear "1990" @default.
• W2066784616 type Work @default.
• W2066784616 sameAs 2066784616 @default.
• W2066784616 citedByCount "2" @default.
• W2066784616 crossrefType "journal-article" @default.
• W2066784616 hasAuthorship W2066784616A5036135855 @default.
• W2066784616 hasAuthorship W2066784616A5046918160 @default.
• W2066784616 hasAuthorship W2066784616A5071911822 @default.
• W2066784616 hasBestOaLocation W20667846161 @default.
• W2066784616 hasConcept C107824862 @default.
• W2066784616 hasConcept C121608353 @default.
• W2066784616 hasConcept C126322002 @default.
• W2066784616 hasConcept C134018914 @default.
• W2066784616 hasConcept C170493617 @default.
• W2066784616 hasConcept C185592680 @default.
• W2066784616 hasConcept C2775960820 @default.
• W2066784616 hasConcept C2776166826 @default.
• W2066784616 hasConcept C2776362946 @default.
• W2066784616 hasConcept C2777164284 @default.
• W2066784616 hasConcept C2777203538 @default.
• W2066784616 hasConcept C2779279991 @default.
• W2066784616 hasConcept C530470458 @default.
• W2066784616 hasConcept C54355233 @default.
• W2066784616 hasConcept C55493867 @default.
• W2066784616 hasConcept C71315377 @default.
• W2066784616 hasConcept C71924100 @default.
• W2066784616 hasConcept C81885089 @default.
• W2066784616 hasConcept C86803240 @default.
• W2066784616 hasConceptScore W2066784616C107824862 @default.
• W2066784616 hasConceptScore W2066784616C121608353 @default.
• W2066784616 hasConceptScore W2066784616C126322002 @default.
• W2066784616 hasConceptScore W2066784616C134018914 @default.
• W2066784616 hasConceptScore W2066784616C170493617 @default.
• W2066784616 hasConceptScore W2066784616C185592680 @default.
• W2066784616 hasConceptScore W2066784616C2775960820 @default.
• W2066784616 hasConceptScore W2066784616C2776166826 @default.
• W2066784616 hasConceptScore W2066784616C2776362946 @default.
• W2066784616 hasConceptScore W2066784616C2777164284 @default.
• W2066784616 hasConceptScore W2066784616C2777203538 @default.
• W2066784616 hasConceptScore W2066784616C2779279991 @default.
• W2066784616 hasConceptScore W2066784616C530470458 @default.
• W2066784616 hasConceptScore W2066784616C54355233 @default.
• W2066784616 hasConceptScore W2066784616C55493867 @default.
• W2066784616 hasConceptScore W2066784616C71315377 @default.
• W2066784616 hasConceptScore W2066784616C71924100 @default.
• W2066784616 hasConceptScore W2066784616C81885089 @default.
• W2066784616 hasConceptScore W2066784616C86803240 @default.
• W2066784616 hasIssue "6" @default.
• W2066784616 hasLocation W20667846161 @default.
• W2066784616 hasLocation W20667846162 @default.
• W2066784616 hasOpenAccess W2066784616 @default.
• W2066784616 hasPrimaryLocation W20667846161 @default.
• W2066784616 hasRelatedWork W1965669711 @default.
• W2066784616 hasRelatedWork W2011193016 @default.
• W2066784616 hasRelatedWork W2018368842 @default.
• W2066784616 hasRelatedWork W2021560856 @default.
• W2066784616 hasRelatedWork W2032603988 @default.
• W2066784616 hasRelatedWork W2040706140 @default.
• W2066784616 hasRelatedWork W2087436166 @default.
• W2066784616 hasRelatedWork W2089781193 @default.
• W2066784616 hasRelatedWork W2110010322 @default.
• W2066784616 hasRelatedWork W2144562624 @default.
• W2066784616 hasVolume "37" @default.
• W2066784616 isParatext "false" @default.
• W2066784616 isRetracted "false" @default.
• W2066784616 magId "2066784616" @default.

• next