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• W2066799558 abstract "The development of topographic maps in the primary visual system is thought to rely on a combination of EphA/ephrin-A interactions and patterned neural activity. Here, we characterize the retinogeniculate and retinocollicular maps of mice mutant for ephrins-A2, -A3, and -A5 (the three ephrin-As expressed in the mouse visual system), mice mutant for the β2 subunit of the nicotinic acetylcholine receptor (that lack early patterned retinal activity), and mice mutant for both ephrin-As and β2. We also provide the first comprehensive anatomical description of the topographic connections between the retina and the dorsal lateral geniculate nucleus. We find that, although ephrin-A2/A3/A5 triple knock-out mice have severe mapping defects in both projections, they do not completely lack topography. Mice lacking β2-dependent retinal activity have nearly normal topography but fail to refine axonal arbors. Mice mutant for both ephrin-As and β2 have synergistic mapping defects that result in a near absence of map in the retinocollicular projection; however, the retinogeniculate projection is not as severely disrupted as the retinocollicular projection is in these mutants. These results show that ephrin-As and patterned retinal activity act together to establish topographic maps, and demonstrate that midbrain and forebrain connections have a differential requirement for ephrin-As and patterned retinal activity in topographic map development." @default.
• W2066799558 created "2016-06-24" @default.
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• W2066799558 date "2006-12-13" @default.
• W2066799558 modified "2023-09-27" @default.
• W2066799558 title "Ephrin-As and Patterned Retinal Activity Act Together in the Development of Topographic Maps in the Primary Visual System" @default.
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• W2066799558 doi "https://doi.org/10.1523/jneurosci.3595-06.2006" @default.
• W2066799558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3664553" @default.
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