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• W2066803419 abstract "Considerable evidence supports the view that D‐type cyclins play a role in G1‐S progression. We found that cyclin D2 directly interacts with Mel‐18, one of the polycomb group gene products in a yeast two hybrid screen. Further, we have determined the binding domains that are required for interaction between cyclin D2 and Mel‐18. The proline/serine‐rich domain (P/S domain) of Mel‐18 is required to interact with cyclin D2, and the N‐terminal region of cyclin D2 is necessary to interact with Mel‐18. A co‐localization study shows that cyclin D2 and Mel‐18 interact within the nucleus. To determine whether Mel‐18 affects cyclin D2 activity, we blocked Mel‐18 expression using an anti‐sense strand system in cyclin D2 over‐expressing cells. The results indicate that cells with reduced Mel‐18 expression levels show more proliferative activity than the controls. These findings are the first report that Mel‐18 directly interacts with cyclin D2 and may inhibit cyclin D2 activity." @default.
• W2066803419 created "2016-06-24" @default.
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• W2066803419 date "2005-09-12" @default.
• W2066803419 modified "2023-10-18" @default.
• W2066803419 title "The polycomb group gene product Mel-18 interacts with cyclin D2 and modulates its activity" @default.
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• W2066803419 doi "https://doi.org/10.1016/j.febslet.2005.08.050" @default.
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