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- W2066803887 abstract "Swine possess an extraordinarily high number of T lymphocytes with the phenotype CD4−CD8− in peripheral blood as well as in lymphoid tissues.This subpopulation is subdivided into at least four subsets defined by the expression of CD2 and three biochemically distinct γ/δ T cell receptors.The four subsets differ largely in their pattern of lymphoid homing in that CD2− subsets, historically referred to as null lymphocytes, predominate in the circulating pool, whereas CD2+ subsets are enriched in lymphoid tissues.Here we document the expression of all three types of γ/δ T cell receptors by CD4−CD8− porcine thymocytes, which provides the first evidence for a thymic origination of all subsets of porcine γ/δ T lymphocytes.The biochemical analysis shows that three distinct γ-chains form disulfide-bonded cell surface heterodimers with a common δ-chain and that glycosylation of all chains is already completed within the thymus.Surprisingly, CD2− subsets, which are known to be enriched among thymic emigrants and which numerically predominate in peripheral blood, are underrepresented in the thymus, suggesting a high export rate." @default.
- W2066803887 created "2016-06-24" @default.
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- W2066803887 date "1989-12-01" @default.
- W2066803887 modified "2023-09-27" @default.
- W2066803887 title "Thymic ontogeny and selection of αβ and γδ T cells" @default.
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- W2066803887 doi "https://doi.org/10.1016/0167-5699(89)90035-2" @default.
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