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- W2066807756 abstract "Fluorescence in situ hybridization (FISH) analysis of metaphase and decondensed free chromatin fibers from Adriamycin (ADR)-sensitive and ADR-resistant murine cells demonstrated a close juxtaposition of topoisomerase IIα <i>(Top2a) </i>and retinoic acid receptor α (<i>Rara</i>) genes in adjacent chromatin in the drug-resistant cells, and a close but separate genetic proximity in normal murine chromatin. This provides physical evidence that the chromosome 11 allelic rearrangement resulting in a chimeric truncated <i>Top2a/Rara</i> transcript in the ADR-resistant cells is due to a novel fusion of the <i>Topo2a</i> and <i>Rara</i> genes. This is the first description of a <i>Rara </i>gene disruption in cells selected for antineoplastic drug resistance." @default.
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- W2066807756 title "Allelic fusion of DNA topoisomerase IIα and retinoic acid receptor α genes in Adriamycin-resistant p388 murine leukemia revealed by fluorescence in situ hybridization" @default.
- W2066807756 doi "https://doi.org/10.1159/000134470" @default.
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