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• W2066814747 abstract "To study the effects of suberoyl bis-hydroxamic acid (SBHA), an inhibitor of histone deacetylases, on the apoptosis of MCF-7 breast cancer cells. Apoptosis in MCF-7 cells induced by SBHA was demonstrated by flow cytometric analysis, morphological observation, and DNA ladder. Mitochondrial membrane potential (ΔΨm) was measured using the fluorescent probe JC-1. The expressions of p53, p21, Bax, and PUMA were determined using RT-PCR or Western blotting analysis after the MCF-7 cells were treated with SBHA or p53 siRNA. SBHA induced apoptosis in MCF-7 cells. The expressions of p53, p21, Bax, and PUMA were induced, and ΔΨm collapsed after treatment with SBHA. p53 siRNA abrogated the SBHA-induced apoptosis and the expressions of p53, p21, Bax, and PUMA. The activation of the p53 pathway is involved in SBHA-induced apoptosis in MCF-7 cells." @default.
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• W2066814747 date "2008-12-01" @default.
• W2066814747 modified "2023-10-04" @default.
• W2066814747 title "Suberoyl bis-hydroxamic acid induces p53-dependent apoptosis of MCF-7 breast cancer cells" @default.
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• W2066814747 doi "https://doi.org/10.1111/j.1745-7254.2008.00906.x" @default.
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