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- W2066822775 abstract "The aim of this report was to improve the real-time imaging of fluorescence laparoscopy with the introduction of an LED light source. We also attempted to determine the optimal fluorophore to improve accurate identification and localization of tumor deposits without the loss of background illumination. Human pancreatic cancer orthotopic models were established with intraperitoneal injections of RFP-expressing FG or BxPC-3, or non-fluorescent BxPC-3 human pancreatic cancer cells into 6-week-old female athymic mice. One to 2 weeks post implantation, diagnostic laparoscopy was performed with a Stryker L9000 LED light source or a Stryker X8000 xenon light source 24 hours after tail vein injection of Alexa 488-conjugated anti-CEA. An attempt was made to detect and localize all cancer lesions under each light mode. After laparoscopy, the animals were sacrificed and abdominal cavities exposed. Images of the lesions were obtained with the Maestro CRI Small Animal Imaging System serving as a positive control. Tumors were collected and processed for histologic review. Fluorescence laparoscopy with the use of a 495-nm emission filter and an LED light source enabled real-time visualization of the fluorescence-labeled tumor metastases in the peritoneal cavity. With adjustments to the LED light source, we could simultaneously detect tumor lesions of different fluorescent colors and surrounding structures with minimal autofluorescence. Overall, fluorescence laparoscopy using the LED light source afforded accurate detection of more lesions compared to standard xenon bright field laparoscopy. In addition, several tumor deposits of less than 1mm were identified and localized under FL. Such lesions were not detected under bright field laparoscopy. All identified lesions, when possible, were verified histologically. In this study, we have thus demonstrated that using an LED light source with adjustments to the red, blue and green wavelengths, we can simultaneously identify fluorescent tumor metastases of different wavelengths without compromising background illumination. The further development of this technology can serve as a novel tool in the staging and treatment of pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5323. doi:10.1158/1538-7445.AM2011-5323" @default.
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- W2066822775 date "2011-04-15" @default.
- W2066822775 modified "2023-09-25" @default.
- W2066822775 title "Abstract 5323: Staging of metastatic pancreatic cancer is facilitated by fluorescence laparoscopy" @default.
- W2066822775 doi "https://doi.org/10.1158/1538-7445.am2011-5323" @default.
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