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- W2066836719 abstract "The toxicological properties of 4-tert-butyl-2-chlorophenyl methyl methylphosphoramidate (Ruelene®) have been studied extensively in laboratory animals. For a single oral administration, the LD50 values ranged from 490 to more than 1000 mg/kg in rabbits, rats, guinea-pigs and dogs.Single oral doses of Ruelene were administered to rats together with each of 14 commercial cholinesterase-inhibiting insecticides. Except for Ruelene with malathion, where the ratio of expected to observed values was 5·3, the effect on LD50 values was additive (with ratios ranging from 0·7 to 2·2). Feeding studies in dogs, carried out over a 12-wk period with 100 ppm malathion plus 20 ppm Ruelene or 10 ppm malathion plus 20 ppm Ruelene, showed no significant evidence of potentiation.In 90-day feeding studies in rats, no ill effects occurred at levels ranging from 30 to 1000 ppm Ruelene, except a peculiarly uniform decrease in blood- and/or brain-cholinesterase activity amounting to 40–60%.A 75-day feeding study in dogs showed no evidence of significant toxicological effect with diets containing 40 or 125 ppm Ruelene. At a level of 250 ppm, blood-cholinesterase activity decreased slightly and minor changes were observed microscopically in the liver.In a 2-yr dietary study in rats, 1000 ppm Ruelene caused slight growth retardation, degeneration of testes, atrophy of hind quarters and slight sciatic nerve degeneration. The only effect at the 100 ppm level was depression of cholinesterase activity in the blood. A multi-generation study in rats showed no effect on reproduction and fertility at dietary levels up to 500 ppm.Beagle dogs were maintained for 2 yr on dietary levels ranging from 10 to 2000 ppm Ruelene. The animals on the highest level of Ruelene manifested gross signs of intoxication and values of serum alkaline phosphatase and transaminase were elevated. These animals, as well as those fed 200 ppm Ruelene, showed depressed plasma- and erythrocyte-cholinesterase activities. Other biochemical and haematological findings and the results of gross and microscopic examination of the tissues were comparable with the controls.On the basis of these findings, an acceptable daily intake for man of 0·05−0·2 mg/kg/day can be calculated for Ruelene." @default.
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- W2066836719 date "1968-01-01" @default.
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- W2066836719 title "Toxicology of 4-tert-butyl-2-chlorophenyl methyl methylphosphoramidate (Ruelene) in laboratory animals" @default.
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- W2066836719 doi "https://doi.org/10.1016/0015-6264(68)90200-9" @default.
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