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• W2066839139 abstract "The paper is devoted to the investigation of microwave irradiation (MW) for the preparation of solvent free solid dispersion (SD). Precisely, sustained release solid dispersions containing different drug-to-polymer ratios were developed by means of microwave technology using ibuprofen (IBU) as a model drug and glyceryl monostarate (Imwitor 900, GM) as a lipophilic sustained release agent. Their physical characterizations were determined by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), hot-stage microscopy (HSM). Through the dissolution rates studies, the in vitro drug performance of the SD was evaluated. The physical characterizations revealed a substantial correspondence of the drug solid state before and after MW treatment while drug-carrier interactions in the SD were attested. The dissolution studies of the irradiated samples showed that the matrices based on Imwitor 900 were able to promote a sustained release of the drug. A mathematical approach suggested that IBU release from solid dispersion was essentially due to matrix erosion. In conclusion we can affirm that the microwave technique could be considered as a new and interesting method to prepare drug-carrier systems." @default.
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• W2066839139 date "2008-01-01" @default.
• W2066839139 modified "2023-10-17" @default.
• W2066839139 title "Sustained-release solid dispersions of ibuprofen prepared by microwave irradiation" @default.
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• W2066839139 doi "https://doi.org/10.1016/s1773-2247(08)50064-5" @default.
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