Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066849799> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2066849799 endingPage "618" @default.
- W2066849799 startingPage "618" @default.
- W2066849799 abstract "Aim: Small bowel mucosal extracellular transglutaminase 2 (TG2)-specific IgA-deposits are found in early developing coeliac disease (CD) before TG2-autoantibodies are measurable in serum. We studied whether such IgA-deposits might be of value in monitoring CD during oats or gluten challenge. Method: 23 CD children in remission were randomized to start either oats (50 g/day) or gluten (wheat, rye, barley and oats, altogether 20 g/day); when small bowel histological relapse was evident after gluten challenge, patients continued with oats but excluded wheat, barley and rye from the diet. Unfixed, frozen jejunal biopsies (at the baseline, after 6 and 24 months challenges) were blindly evaluated for the presence of TG2-specific IgA-deposits using double-colour immunofluorescence, and their intensity was graded 0-3. The results were compared to serum TG2-antibodies and jejunal mucosal morphology and inflammation. Results: At the baseline serumTG2-antibodies were negative in all 23 patients, but 4 of them had minimal (grade 1/2−1 1/2;) small bowel mucosal TG2-specific IgA-deposits, mainly around mucosal vessels. In gluten challenge group, jejunal histological relapse was evident and the densities of IgA-deposits clearly increased (grade 2-3) within 6 months in all 10 patients; afterwards while consuming gluten-free diet with oats jejunal mucosa recovered fully and densities of TG2-specific IgA-deposits decreased being negative in all after two years withoats. In oats challenge group in children having CD in remission two patients withdrew in a month from the study because of abdominal symptoms; they had no inflammation or IgA-depositions in jejunal mucosa after consumingoats. The rest 11 in oats group remained in clinical and histological remission; after 2-years with oats mucosal IgA-deposits were negative in 9, two had minimal depositions as was seen at the baseline of the study. Summary: Non-toxicity of oats in CD was indicated by small bowel mucosalTG2-specific IgA-deposits; they correlated well with mucosal villousmorphology and inflammation and serum TG2-antibodies. Conclusions: Small bowel mucosal TG2-antibody responses can be used in monitoring CD." @default.
- W2066849799 created "2016-06-24" @default.
- W2066849799 creator A5003543575 @default.
- W2066849799 creator A5035650600 @default.
- W2066849799 creator A5043533006 @default.
- W2066849799 creator A5062894576 @default.
- W2066849799 creator A5073638108 @default.
- W2066849799 date "2005-05-01" @default.
- W2066849799 modified "2023-09-26" @default.
- W2066849799 title "SMALL BOWEL MUCOSAL TRANSGLUTAMINASE AUTOANTIBODIES DURING OATS AND GLUTEN CHALLENGE IN COELIAC DISEASE" @default.
- W2066849799 doi "https://doi.org/10.1097/00005176-200505000-00026" @default.
- W2066849799 hasPublicationYear "2005" @default.
- W2066849799 type Work @default.
- W2066849799 sameAs 2066849799 @default.
- W2066849799 citedByCount "0" @default.
- W2066849799 crossrefType "journal-article" @default.
- W2066849799 hasAuthorship W2066849799A5003543575 @default.
- W2066849799 hasAuthorship W2066849799A5035650600 @default.
- W2066849799 hasAuthorship W2066849799A5043533006 @default.
- W2066849799 hasAuthorship W2066849799A5062894576 @default.
- W2066849799 hasAuthorship W2066849799A5073638108 @default.
- W2066849799 hasConcept C126322002 @default.
- W2066849799 hasConcept C142724271 @default.
- W2066849799 hasConcept C159654299 @default.
- W2066849799 hasConcept C163764329 @default.
- W2066849799 hasConcept C178498320 @default.
- W2066849799 hasConcept C181199279 @default.
- W2066849799 hasConcept C203014093 @default.
- W2066849799 hasConcept C2776336767 @default.
- W2066849799 hasConcept C2776366702 @default.
- W2066849799 hasConcept C2777882243 @default.
- W2066849799 hasConcept C2779102806 @default.
- W2066849799 hasConcept C2779134260 @default.
- W2066849799 hasConcept C2780349322 @default.
- W2066849799 hasConcept C2780648854 @default.
- W2066849799 hasConcept C2780898057 @default.
- W2066849799 hasConcept C2993432164 @default.
- W2066849799 hasConcept C3019118998 @default.
- W2066849799 hasConcept C3019368612 @default.
- W2066849799 hasConcept C55493867 @default.
- W2066849799 hasConcept C71924100 @default.
- W2066849799 hasConcept C86803240 @default.
- W2066849799 hasConcept C90924648 @default.
- W2066849799 hasConceptScore W2066849799C126322002 @default.
- W2066849799 hasConceptScore W2066849799C142724271 @default.
- W2066849799 hasConceptScore W2066849799C159654299 @default.
- W2066849799 hasConceptScore W2066849799C163764329 @default.
- W2066849799 hasConceptScore W2066849799C178498320 @default.
- W2066849799 hasConceptScore W2066849799C181199279 @default.
- W2066849799 hasConceptScore W2066849799C203014093 @default.
- W2066849799 hasConceptScore W2066849799C2776336767 @default.
- W2066849799 hasConceptScore W2066849799C2776366702 @default.
- W2066849799 hasConceptScore W2066849799C2777882243 @default.
- W2066849799 hasConceptScore W2066849799C2779102806 @default.
- W2066849799 hasConceptScore W2066849799C2779134260 @default.
- W2066849799 hasConceptScore W2066849799C2780349322 @default.
- W2066849799 hasConceptScore W2066849799C2780648854 @default.
- W2066849799 hasConceptScore W2066849799C2780898057 @default.
- W2066849799 hasConceptScore W2066849799C2993432164 @default.
- W2066849799 hasConceptScore W2066849799C3019118998 @default.
- W2066849799 hasConceptScore W2066849799C3019368612 @default.
- W2066849799 hasConceptScore W2066849799C55493867 @default.
- W2066849799 hasConceptScore W2066849799C71924100 @default.
- W2066849799 hasConceptScore W2066849799C86803240 @default.
- W2066849799 hasConceptScore W2066849799C90924648 @default.
- W2066849799 hasIssue "5" @default.
- W2066849799 hasLocation W20668497991 @default.
- W2066849799 hasOpenAccess W2066849799 @default.
- W2066849799 hasPrimaryLocation W20668497991 @default.
- W2066849799 hasRelatedWork W1971601403 @default.
- W2066849799 hasRelatedWork W2022135535 @default.
- W2066849799 hasRelatedWork W2033664948 @default.
- W2066849799 hasRelatedWork W2042944197 @default.
- W2066849799 hasRelatedWork W2065433711 @default.
- W2066849799 hasRelatedWork W2109112563 @default.
- W2066849799 hasRelatedWork W2153137387 @default.
- W2066849799 hasRelatedWork W2411662263 @default.
- W2066849799 hasRelatedWork W2516720944 @default.
- W2066849799 hasRelatedWork W2898383728 @default.
- W2066849799 hasVolume "40" @default.
- W2066849799 isParatext "false" @default.
- W2066849799 isRetracted "false" @default.
- W2066849799 magId "2066849799" @default.
- W2066849799 workType "article" @default.