FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066849968> ?p ?o ?g. }

• W2066849968 endingPage "528" @default.
• W2066849968 startingPage "525" @default.
• W2066849968 abstract "Abstract Objective: The molecular mechanisms underpinning the loss of skeletal muscle mass and strength associated with insulin resistance remain to be extensively investigated. There is mounting recognition that certain ligands of the transforming growth factor (TGF)‐β family are upregulated in insulin resistant states, including obesity. This study analyses the expression of potent ligands of this family, TGF‐β1 and myostatin (MSTN) and downstream components of the canonical TGF‐β family signaling pathway (Smads) in skeletal muscle from lean and insulin resistant obese subjects. Design and Methods: Biopsies taken from the rectus abdominis muscle of lean ( n = 13) and obese subjects ( n = 20) were analyzed for the expression of TGF‐β1 and MSTN as well as TGF‐β signaling components, Smad2, 3, and 4, and transcription of the muscle regulatory factors (MRFs), MyoD and myogenin. Results: Increases in Smad2 and Smad3 phosphorylation, Smad4 and total Smad3 were observed to be coincident with altered transcription of MyoD and myogenin. TGF‐β1 and MSTN protein levels were not significantly altered. Conclusion: Thus, increased Smad signaling is likely to account for, at least, a proportion of obesity and insulin resistance‐related muscle atrophy through reduced MRF, particularly MyoD, transcription. The major regulatory ligand may not be MSTN and further members of the TGF‐β1 superfamily should be considered." @default.
• W2066849968 created "2016-06-24" @default.
• W2066849968 creator A5024814922 @default.
• W2066849968 creator A5033586136 @default.
• W2066849968 creator A5041946486 @default.
• W2066849968 creator A5070035519 @default.
• W2066849968 creator A5072438559 @default.
• W2066849968 date "2013-03-01" @default.
• W2066849968 modified "2023-10-18" @default.
• W2066849968 title "Increased Smad signaling and reduced MRF expression in skeletal muscle from obese subjects" @default.
• W2066849968 cites W1986156265 @default.
• W2066849968 cites W1990270713 @default.
• W2066849968 cites W2028966038 @default.
• W2066849968 cites W2031882974 @default.
• W2066849968 cites W2036329632 @default.
• W2066849968 cites W2053079324 @default.
• W2066849968 cites W2102368545 @default.
• W2066849968 cites W2106719297 @default.
• W2066849968 cites W2116961946 @default.
• W2066849968 cites W2129871296 @default.
• W2066849968 cites W2132813206 @default.
• W2066849968 cites W2153289066 @default.
• W2066849968 cites W2154970636 @default.
• W2066849968 cites W2158254766 @default.
• W2066849968 cites W2164418602 @default.
• W2066849968 doi "https://doi.org/10.1002/oby.20070" @default.
• W2066849968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23404842" @default.
• W2066849968 hasPublicationYear "2013" @default.
• W2066849968 type Work @default.
• W2066849968 sameAs 2066849968 @default.
• W2066849968 citedByCount "38" @default.
• W2066849968 countsByYear W20668499682013 @default.
• W2066849968 countsByYear W20668499682014 @default.
• W2066849968 countsByYear W20668499682015 @default.
• W2066849968 countsByYear W20668499682017 @default.
• W2066849968 countsByYear W20668499682018 @default.
• W2066849968 countsByYear W20668499682019 @default.
• W2066849968 countsByYear W20668499682020 @default.
• W2066849968 countsByYear W20668499682021 @default.
• W2066849968 countsByYear W20668499682022 @default.
• W2066849968 countsByYear W20668499682023 @default.
• W2066849968 crossrefType "journal-article" @default.
• W2066849968 hasAuthorship W2066849968A5024814922 @default.
• W2066849968 hasAuthorship W2066849968A5033586136 @default.
• W2066849968 hasAuthorship W2066849968A5041946486 @default.
• W2066849968 hasAuthorship W2066849968A5070035519 @default.
• W2066849968 hasAuthorship W2066849968A5072438559 @default.
• W2066849968 hasConcept C104317684 @default.
• W2066849968 hasConcept C118131993 @default.
• W2066849968 hasConcept C126322002 @default.
• W2066849968 hasConcept C134018914 @default.
• W2066849968 hasConcept C207200792 @default.
• W2066849968 hasConcept C2777391703 @default.
• W2066849968 hasConcept C2777488582 @default.
• W2066849968 hasConcept C2778106681 @default.
• W2066849968 hasConcept C2779306644 @default.
• W2066849968 hasConcept C2779959927 @default.
• W2066849968 hasConcept C2781080636 @default.
• W2066849968 hasConcept C3763915 @default.
• W2066849968 hasConcept C54355233 @default.
• W2066849968 hasConcept C71924100 @default.
• W2066849968 hasConcept C86339819 @default.
• W2066849968 hasConcept C86803240 @default.
• W2066849968 hasConcept C97816823 @default.
• W2066849968 hasConceptScore W2066849968C104317684 @default.
• W2066849968 hasConceptScore W2066849968C118131993 @default.
• W2066849968 hasConceptScore W2066849968C126322002 @default.
• W2066849968 hasConceptScore W2066849968C134018914 @default.
• W2066849968 hasConceptScore W2066849968C207200792 @default.
• W2066849968 hasConceptScore W2066849968C2777391703 @default.
• W2066849968 hasConceptScore W2066849968C2777488582 @default.
• W2066849968 hasConceptScore W2066849968C2778106681 @default.
• W2066849968 hasConceptScore W2066849968C2779306644 @default.
• W2066849968 hasConceptScore W2066849968C2779959927 @default.
• W2066849968 hasConceptScore W2066849968C2781080636 @default.
• W2066849968 hasConceptScore W2066849968C3763915 @default.
• W2066849968 hasConceptScore W2066849968C54355233 @default.
• W2066849968 hasConceptScore W2066849968C71924100 @default.
• W2066849968 hasConceptScore W2066849968C86339819 @default.
• W2066849968 hasConceptScore W2066849968C86803240 @default.
• W2066849968 hasConceptScore W2066849968C97816823 @default.
• W2066849968 hasIssue "3" @default.
• W2066849968 hasLocation W20668499681 @default.
• W2066849968 hasLocation W20668499682 @default.
• W2066849968 hasOpenAccess W2066849968 @default.
• W2066849968 hasPrimaryLocation W20668499681 @default.
• W2066849968 hasRelatedWork W1636541108 @default.
• W2066849968 hasRelatedWork W1884838825 @default.
• W2066849968 hasRelatedWork W1999820213 @default.
• W2066849968 hasRelatedWork W2065829112 @default.
• W2066849968 hasRelatedWork W2079826520 @default.
• W2066849968 hasRelatedWork W2132832223 @default.
• W2066849968 hasRelatedWork W2144106893 @default.
• W2066849968 hasRelatedWork W2157491055 @default.
• W2066849968 hasRelatedWork W2167315148 @default.
• W2066849968 hasRelatedWork W4229490071 @default.
• W2066849968 hasVolume "21" @default.
• W2066849968 isParatext "false" @default.

• next