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- W2066851021 abstract "Introduction: Vitamin D deficiency is prevalent among patients with chronic obstructive pulmonary disease (COPD) and comes to be more frequent with increased disease severity. We aimed to assess the role of vitamin D supplementation in patients with severe COPD. Patients and methods: We studied 30 patients with severe COPD and vitamin D deficiency. All patients received oral vitamin D3 50,000 IU once weekly for 8 weeks, followed by a daily dose of 800 IU thereafter. Pulmonary function tests, six minute walk test (6MWT), maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), C-reactive protein (CRP), and serum vita- min D level were assessed at the start of the study and 1 year later. The frequency of exacerbations was recorded a year before and a year after vitamin D supplementation. Results: The mean serum vitamin D level was 11.80 ± 2.40 ng/dl and reached 55.30 ± 5.65 ng/ dl a year after vitamin D intake (p < 0.001). We found a significant improvement in dyspnea scale (p < 0.003), 6MWT (p < 0.001), MVV (p < 0.001), MIP (p = 0.006), MEP (p < 0.001), coupled with a decrease in disease exacerbations (p < 0.001) and CRP (p < 0.001) a year after vitamin D replacement. However, the FEV1 and FVC did not differ significantly. Conclusion: Vitamin D replacement improved dyspnea, physical performance and decreased the frequency of exacerbation in severe COPD patients with vitamin D deficiency. a 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of The Egyptian Society of Chest Diseases and Tuberculosis. This is an open access article under the CC BY-NC-ND license (http://" @default.
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- W2066851021 date "2015-04-01" @default.
- W2066851021 modified "2023-09-26" @default.
- W2066851021 title "Effect of vitamin D replacement in chronic obstructive pulmonary disease patients with vitamin D deficiency" @default.
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- W2066851021 doi "https://doi.org/10.1016/j.ejcdt.2015.01.002" @default.
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