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• W2066852210 endingPage "81" @default.
• W2066852210 startingPage "71" @default.
• W2066852210 abstract "The murine 2'-5' oligoadenylate synthetase 1a (Oas1a) and Oas1b genes are type 1 IFN responsive genes. Oas1a is an active synthetase with broad antiviral activity mediated through RNase L. Oas1b is inactive but can inhibit Oas1a synthetase activity and mediate a flavivirus-specific antiviral activity through an unknown RNase L-independent mechanism. Analysis of promoter elements regulating gene transcription confirmed that an IFN-stimulated response element (ISRE) is required for IFN beta-activation but neither the overlapping IRF binding site present in both promoters nor the adjacent Oas1b NF-kappa B site is required. Mutation of the overlapping STAT site negatively affected IFN beta-induction of Oas1a but not of Oas1b. Also, IFN beta induction of Oas1a was STAT1- and STAT2-dependent, while induction of Oas1b was STAT1-independent but STAT2-dependent. The two promoters differ at a single nucleotide in the STAT site. The data indicate that these two duplicated genes can be differentially regulated by IFN beta." @default.
• W2066852210 created "2016-06-24" @default.
• W2066852210 creator A5007894843 @default.
• W2066852210 creator A5083641020 @default.
• W2066852210 creator A5089100022 @default.
• W2066852210 date "2012-04-01" @default.
• W2066852210 modified "2023-10-02" @default.
• W2066852210 title "Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation" @default.
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• W2066852210 doi "https://doi.org/10.1016/j.virol.2011.11.025" @default.
• W2066852210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3288655" @default.
• W2066852210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22305621" @default.
• W2066852210 hasPublicationYear "2012" @default.
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