FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066865635> ?p ?o ?g. }

• W2066865635 endingPage "4506" @default.
• W2066865635 startingPage "4506" @default.
• W2066865635 abstract "To evaluate the transscleral delivery of Oregon Green-labeled triamcinolone acetonide (OGTA) into the eye.Ex vivo experiments were performed on rabbit sclera in a Lucite block perfusion chamber. Two hundred microliters OGTA (5 mg/mL) was placed on the outer surface of the sclera for 24 hours. The exposed sclera was divided into two pieces; one half for a washout of OGTA and the other for histology. The concentration of OGTA that diffused through the sclera (n = 6) was measured by fluorometry. Two hundred microliters of OGTA (5 mg/mL) was also injected subtenon into live (n = 6) and euthanatized rabbits (n = 3). Intraocular OGTA concentrations were measured by ocular fluorophotometry.The permeability constant for the transscleral diffusion (K(trans)) of OGTA was 1.12 x 10(-7) +/- 0.08 cm/s (n = 8) during the steady state perfusion. Washout tests showed higher OGTA concentration in the sclera exposed to OGTA for 4 hours than in that exposed for 1 hour. Fluorescent microscopy showed OGTA fluorescence throughout the exposed sclera, as evidence of scleral penetration of OGTA. The maximum OGTA concentration in the retina/choroid after subtenon injection was 25.77 +/- 10.26 ng/mL in the live rabbit at 3 hours and 84.68 +/- 21.04 ng/mL in the euthanatized rabbits at 8 hours.OGTA is capable of diffusing across isolated rabbit sclera ex vivo and into the retina/choroid via transscleral diffusion from a subtenon depot in vivo. Conjunctival and choroidal circulation decreased the drug delivery of OGTA." @default.
• W2066865635 created "2016-06-24" @default.
• W2066865635 creator A5028590343 @default.
• W2066865635 creator A5038576932 @default.
• W2066865635 creator A5059051692 @default.
• W2066865635 creator A5083984022 @default.
• W2066865635 creator A5088651146 @default.
• W2066865635 date "2008-10-01" @default.
• W2066865635 modified "2023-10-16" @default.
• W2066865635 title "Pharmacokinetics of Intraocular Drug Delivery of Oregon Green 488–Labeled Triamcinolone by Subtenon Injection Using Ocular Fluorophotometry in Rabbit Eyes" @default.
• W2066865635 cites W1170962552 @default.
• W2066865635 cites W124380345 @default.
• W2066865635 cites W191502379 @default.
• W2066865635 cites W1966039402 @default.
• W2066865635 cites W1971098776 @default.
• W2066865635 cites W2000523918 @default.
• W2066865635 cites W2001733471 @default.
• W2066865635 cites W2009076907 @default.
• W2066865635 cites W2016393330 @default.
• W2066865635 cites W2021592080 @default.
• W2066865635 cites W2022758760 @default.
• W2066865635 cites W2039214400 @default.
• W2066865635 cites W2040236977 @default.
• W2066865635 cites W2044001388 @default.
• W2066865635 cites W2049695644 @default.
• W2066865635 cites W2049726879 @default.
• W2066865635 cites W2051900738 @default.
• W2066865635 cites W2065192615 @default.
• W2066865635 cites W2066484997 @default.
• W2066865635 cites W2068789854 @default.
• W2066865635 cites W2070233546 @default.
• W2066865635 cites W2070554206 @default.
• W2066865635 cites W2077250374 @default.
• W2066865635 cites W2083092631 @default.
• W2066865635 cites W2105975459 @default.
• W2066865635 cites W2106114981 @default.
• W2066865635 cites W2121182991 @default.
• W2066865635 cites W2128326557 @default.
• W2066865635 cites W2134178766 @default.
• W2066865635 cites W2178220402 @default.
• W2066865635 cites W2412384317 @default.
• W2066865635 cites W2916371385 @default.
• W2066865635 doi "https://doi.org/10.1167/iovs.08-1989" @default.
• W2066865635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18503001" @default.
• W2066865635 hasPublicationYear "2008" @default.
• W2066865635 type Work @default.
• W2066865635 sameAs 2066865635 @default.
• W2066865635 citedByCount "31" @default.
• W2066865635 countsByYear W20668656352012 @default.
• W2066865635 countsByYear W20668656352013 @default.
• W2066865635 countsByYear W20668656352014 @default.
• W2066865635 countsByYear W20668656352015 @default.
• W2066865635 countsByYear W20668656352016 @default.
• W2066865635 countsByYear W20668656352017 @default.
• W2066865635 countsByYear W20668656352019 @default.
• W2066865635 countsByYear W20668656352021 @default.
• W2066865635 countsByYear W20668656352022 @default.
• W2066865635 crossrefType "journal-article" @default.
• W2066865635 hasAuthorship W2066865635A5028590343 @default.
• W2066865635 hasAuthorship W2066865635A5038576932 @default.
• W2066865635 hasAuthorship W2066865635A5059051692 @default.
• W2066865635 hasAuthorship W2066865635A5083984022 @default.
• W2066865635 hasAuthorship W2066865635A5088651146 @default.
• W2066865635 hasConcept C112705442 @default.
• W2066865635 hasConcept C118487528 @default.
• W2066865635 hasConcept C150903083 @default.
• W2066865635 hasConcept C169760540 @default.
• W2066865635 hasConcept C178790620 @default.
• W2066865635 hasConcept C185592680 @default.
• W2066865635 hasConcept C207001950 @default.
• W2066865635 hasConcept C26291073 @default.
• W2066865635 hasConcept C2776694393 @default.
• W2066865635 hasConcept C2777093970 @default.
• W2066865635 hasConcept C2777100477 @default.
• W2066865635 hasConcept C2778903070 @default.
• W2066865635 hasConcept C2779820397 @default.
• W2066865635 hasConcept C71924100 @default.
• W2066865635 hasConcept C86803240 @default.
• W2066865635 hasConcept C98274493 @default.
• W2066865635 hasConceptScore W2066865635C112705442 @default.
• W2066865635 hasConceptScore W2066865635C118487528 @default.
• W2066865635 hasConceptScore W2066865635C150903083 @default.
• W2066865635 hasConceptScore W2066865635C169760540 @default.
• W2066865635 hasConceptScore W2066865635C178790620 @default.
• W2066865635 hasConceptScore W2066865635C185592680 @default.
• W2066865635 hasConceptScore W2066865635C207001950 @default.
• W2066865635 hasConceptScore W2066865635C26291073 @default.
• W2066865635 hasConceptScore W2066865635C2776694393 @default.
• W2066865635 hasConceptScore W2066865635C2777093970 @default.
• W2066865635 hasConceptScore W2066865635C2777100477 @default.
• W2066865635 hasConceptScore W2066865635C2778903070 @default.
• W2066865635 hasConceptScore W2066865635C2779820397 @default.
• W2066865635 hasConceptScore W2066865635C71924100 @default.
• W2066865635 hasConceptScore W2066865635C86803240 @default.
• W2066865635 hasConceptScore W2066865635C98274493 @default.
• W2066865635 hasIssue "10" @default.
• W2066865635 hasLocation W20668656351 @default.
• W2066865635 hasLocation W20668656352 @default.

• next