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- W2066872011 abstract "The nature of C-5 substituent and the configuration at C-5 carbon of 2,3-diphenyltetrahydrofurans, with chiral centres at C-2, C-3 and C-5, show a remarkable influence on their COX-2 inhibition and selectivity. Out of the eight compounds investigated here, 1b with COOH group and R* configuration at C-5, and 2d with CH2SCH2CH3 group and S* configuration at C-5 have been identified as lead molecules for further studies on COX-2 inhibition." @default.
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- W2066872011 date "2006-12-01" @default.
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- W2066872011 title "5-Substituted-2,3-diphenyltetrahydrofurans: A new class of moderately selective COX-2 inhibitors" @default.
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- W2066872011 doi "https://doi.org/10.1016/j.bmc.2006.07.044" @default.
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