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- W2066872364 abstract "Proteolytic cleavage of the cohesin subunit Scc1 is a consistent feature of anaphase onset, although temporal differences exist between eukaryotes in cohesin loss from chromosome arms, as distinct from centromeres. We describe the effects of genetic deletion of Scc1 in chicken DT40 cells. Scc1 loss caused premature sister chromatid separation but did not disrupt chromosome condensation. Scc1 mutants showed defective repair of spontaneous and induced DNA damage. Scc1-deficient cells frequently failed to complete metaphase chromosome alignment and showed chromosome segregation defects, suggesting aberrant kinetochore function. Notably, the chromosome passenger INCENP did not localize normally to centromeres, while the constitutive kinetochore proteins CENP-C and CENP-H behaved normally. These results suggest a role for Scc1 in mitotic regulation, along with cohesion." @default.
- W2066872364 created "2016-06-24" @default.
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- W2066872364 date "2001-12-01" @default.
- W2066872364 modified "2023-09-30" @default.
- W2066872364 title "Scc1/Rad21/Mcd1 Is Required for Sister Chromatid Cohesion and Kinetochore Function in Vertebrate Cells" @default.
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- W2066872364 doi "https://doi.org/10.1016/s1534-5807(01)00088-0" @default.
- W2066872364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11740938" @default.
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