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• W2066873025 abstract "X-ray studies of phosphoglycerate kinase (EC 2.7.2.3, PGK) have shown that the enzyme's single polypeptide chain is organized into two separate domains that correspond to the N- and C-terminal halves of the chain. Substrate binding studies and the incorporation of the complete amino acid sequence of horse-muscle PGK into its X-ray model suggest that the C-domain is an ADP/ATP binding unit and that the N-terminal domain contains the phosphoglycerate binding site and the active site located in a prominent cluster of positively charged residues. Because the distance between these two sites is 12–15 Å, a hinge-bending of 10°–20° has been proposed to bring the two sites together for catalysis. Independent solution studies of yeast PGK have shown that the radius of gyration decreases significantly on the formation of the ternary complex. This change has been interpreted in terms of a 9°–12° rotation about a hinge in the interdomain region that brings the two domains together. We suggest here a structural basis for the proposed hinge-bending that involves the rotation of the two helices that form the domain interface about their contact normal carrying their respective domains with them." @default.
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• W2066873025 date "2009-01-12" @default.
• W2066873025 modified "2023-10-15" @default.
• W2066873025 title "A “helix-scissors” mechanism for the hinge-bending conformational change in phosphoglycerate kinase" @default.
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• W2066873025 doi "https://doi.org/10.1111/j.1399-3011.1986.tb01040.x" @default.
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