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• W2066873077 abstract "Objective The purpose of this study was to assess the tocolytic effect of AS604872, an orally active, potent, and selective prostanoid prostaglandin F2α receptor (FP) antagonist. Study Design Compound AS604872 was characterized and tested for its ability to block uterine contraction and delay preterm parturition in rodent models. Results AS604872 inhibited spontaneous uterine contractions in pregnant rat near term. In pregnant mouse, AS604872 delayed parturition induced by either the antiprogesterone RU-486 or the endotoxin lipopolysaccharide. Pups from treated mothers were delivered alive. The efficacy of AS604872 was superior to the β-mimetic drug ritodrine. Combination of AS604872 and ritodrine showed an additive inhibitory effect on spontaneous uterine contractions in rat. Conclusion A selective antagonist of the FP receptor suppresses uterine contractility and delays labor. Our findings identify a new potential modality for the pharmacological management of preterm labor. The purpose of this study was to assess the tocolytic effect of AS604872, an orally active, potent, and selective prostanoid prostaglandin F2α receptor (FP) antagonist. Compound AS604872 was characterized and tested for its ability to block uterine contraction and delay preterm parturition in rodent models. AS604872 inhibited spontaneous uterine contractions in pregnant rat near term. In pregnant mouse, AS604872 delayed parturition induced by either the antiprogesterone RU-486 or the endotoxin lipopolysaccharide. Pups from treated mothers were delivered alive. The efficacy of AS604872 was superior to the β-mimetic drug ritodrine. Combination of AS604872 and ritodrine showed an additive inhibitory effect on spontaneous uterine contractions in rat. A selective antagonist of the FP receptor suppresses uterine contractility and delays labor. Our findings identify a new potential modality for the pharmacological management of preterm labor." @default.
• W2066873077 created "2016-06-24" @default.
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• W2066873077 date "2007-07-01" @default.
• W2066873077 modified "2023-10-03" @default.
• W2066873077 title "Arrest of preterm labor in rat and mouse by an oral and selective nonprostanoid antagonist of the prostaglandin F2α receptor (FP)" @default.
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• W2066873077 doi "https://doi.org/10.1016/j.ajog.2007.02.010" @default.
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