Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066877718> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2066877718 endingPage "62" @default.
- W2066877718 startingPage "49" @default.
- W2066877718 abstract "A new hypothesis concerning the physiological role of corticosteriod-binding proteins is proposed: These proteins increase the specificity of the adrenocortical system by determining the distribution of corticosteroid signals. Increases in the levels of the binding proteins are postulated to distribute adrenocortical hormonal signals toward organs with proteinpermeable vascular beds. The hypothesis was found to have physicochemical consistency by computer simulation of the multiple mass action and transport equations involved. Liver and pancreas of the rat appear to be members of 2 different classes of corticosteroid-sensitive target tissues. The enzyme alanine aminotransferase (AAT) is corticosteroid-inducible in both tissues, yet when transcortin levels and the total corticosteronecorticosterone concentration are both increased by prolonged estrogen treatment, only the hepatic enzyme responds with increased activity. Hepatic and pancreatic AAT were also induced in both sexes by dexamethasone, a synthetic steroid which is more potent than corticosterone. In contrast, corticosterone, which is more extensively bound in the plasma of females than of males, increases the enzymes in male liver and pancreas and female liver, but not in the female pancreas. The failure of the dexamethasonesensitive enzyme in the female pancreas to respond to a dose of corticosterone which is effective in the liver of both sexes and in the pancreas of the male rat was assumed to be based on the increased binding of corticosterone by the plasma of females. (Endocrinology84: 49, 1969)" @default.
- W2066877718 created "2016-06-24" @default.
- W2066877718 creator A5013248598 @default.
- W2066877718 creator A5021008510 @default.
- W2066877718 creator A5059593950 @default.
- W2066877718 date "1969-01-01" @default.
- W2066877718 modified "2023-10-15" @default.
- W2066877718 title "Protein Binding and the Biological Activity of Corticosteroids: In Vivo Induction of Hepatic and Pancreatic Alanine Aminotransferases by Corticosteroids in Normal and Estrogen-Treated Rats<sup>1</sup>" @default.
- W2066877718 doi "https://doi.org/10.1210/endo-84-1-49" @default.
- W2066877718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5818127" @default.
- W2066877718 hasPublicationYear "1969" @default.
- W2066877718 type Work @default.
- W2066877718 sameAs 2066877718 @default.
- W2066877718 citedByCount "123" @default.
- W2066877718 countsByYear W20668777182012 @default.
- W2066877718 countsByYear W20668777182013 @default.
- W2066877718 crossrefType "journal-article" @default.
- W2066877718 hasAuthorship W2066877718A5013248598 @default.
- W2066877718 hasAuthorship W2066877718A5021008510 @default.
- W2066877718 hasAuthorship W2066877718A5059593950 @default.
- W2066877718 hasConcept C126322002 @default.
- W2066877718 hasConcept C134018914 @default.
- W2066877718 hasConcept C150903083 @default.
- W2066877718 hasConcept C207001950 @default.
- W2066877718 hasConcept C2776804153 @default.
- W2066877718 hasConcept C2777164284 @default.
- W2066877718 hasConcept C2778764654 @default.
- W2066877718 hasConcept C2780352252 @default.
- W2066877718 hasConcept C2780401358 @default.
- W2066877718 hasConcept C71315377 @default.
- W2066877718 hasConcept C71924100 @default.
- W2066877718 hasConcept C81358767 @default.
- W2066877718 hasConcept C86803240 @default.
- W2066877718 hasConcept C90134679 @default.
- W2066877718 hasConceptScore W2066877718C126322002 @default.
- W2066877718 hasConceptScore W2066877718C134018914 @default.
- W2066877718 hasConceptScore W2066877718C150903083 @default.
- W2066877718 hasConceptScore W2066877718C207001950 @default.
- W2066877718 hasConceptScore W2066877718C2776804153 @default.
- W2066877718 hasConceptScore W2066877718C2777164284 @default.
- W2066877718 hasConceptScore W2066877718C2778764654 @default.
- W2066877718 hasConceptScore W2066877718C2780352252 @default.
- W2066877718 hasConceptScore W2066877718C2780401358 @default.
- W2066877718 hasConceptScore W2066877718C71315377 @default.
- W2066877718 hasConceptScore W2066877718C71924100 @default.
- W2066877718 hasConceptScore W2066877718C81358767 @default.
- W2066877718 hasConceptScore W2066877718C86803240 @default.
- W2066877718 hasConceptScore W2066877718C90134679 @default.
- W2066877718 hasIssue "1" @default.
- W2066877718 hasLocation W20668777181 @default.
- W2066877718 hasLocation W20668777182 @default.
- W2066877718 hasOpenAccess W2066877718 @default.
- W2066877718 hasPrimaryLocation W20668777181 @default.
- W2066877718 hasRelatedWork W1966074030 @default.
- W2066877718 hasRelatedWork W2021678768 @default.
- W2066877718 hasRelatedWork W2069074603 @default.
- W2066877718 hasRelatedWork W2082982937 @default.
- W2066877718 hasRelatedWork W2090722260 @default.
- W2066877718 hasRelatedWork W2098897563 @default.
- W2066877718 hasRelatedWork W2128756582 @default.
- W2066877718 hasRelatedWork W2141854202 @default.
- W2066877718 hasRelatedWork W2346514098 @default.
- W2066877718 hasRelatedWork W2412740331 @default.
- W2066877718 hasVolume "84" @default.
- W2066877718 isParatext "false" @default.
- W2066877718 isRetracted "false" @default.
- W2066877718 magId "2066877718" @default.
- W2066877718 workType "article" @default.