Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066881823> ?p ?o ?g. }
- W2066881823 endingPage "653" @default.
- W2066881823 startingPage "646" @default.
- W2066881823 abstract "Amyloid β-protein (Aβ) aggregation is considered to be a critical step in the neurodegeneration of Alzheimer's disease (AD). In addition to Aβ, many proteins aggregate into the amyloid state, in which they form elongated fibers with spines comprising stranded β-sheets. However, the cross-seeding effects of other protein aggregates on Aβ aggregation pathways are not completely clear. To investigate the cross-seeding effects of exogenous and human non-CNS amyloidogenic proteins on Aβ aggregation pathways, we examined whether and how sonicated fibrils of casein, fibroin, sericin, actin, and islet amyloid polypeptide affected Aβ40 and Aβ42 aggregation pathways using the thioflavin T assay and electron microscopy. Interestingly, the fibrillar seeds of all amyloidogenic proteins functioned as seeds. The cross-seeding effect of actin was stronger but that of fibroin was weaker than that of other proteins. Furthermore, our nuclear magnetic resonance spectroscopic studies identified the binding sites of Aβ with the amyloidogenic proteins. Our results indicate that the amyloidogenic proteins, including those contained in foods and cosmetics, contribute to Aβ aggregation by binding to Aβ, suggesting their possible roles in the propagation of Aβ amyloidosis." @default.
- W2066881823 created "2016-06-24" @default.
- W2066881823 creator A5003713761 @default.
- W2066881823 creator A5011533166 @default.
- W2066881823 creator A5017255080 @default.
- W2066881823 creator A5047847751 @default.
- W2066881823 creator A5066133855 @default.
- W2066881823 creator A5085401513 @default.
- W2066881823 date "2014-04-01" @default.
- W2066881823 modified "2023-10-11" @default.
- W2066881823 title "Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation" @default.
- W2066881823 cites W1487727801 @default.
- W2066881823 cites W1531667149 @default.
- W2066881823 cites W1571248124 @default.
- W2066881823 cites W1588296570 @default.
- W2066881823 cites W1599226649 @default.
- W2066881823 cites W1777612024 @default.
- W2066881823 cites W1928837524 @default.
- W2066881823 cites W1970736092 @default.
- W2066881823 cites W1973056215 @default.
- W2066881823 cites W1980115442 @default.
- W2066881823 cites W2004317281 @default.
- W2066881823 cites W2005361764 @default.
- W2066881823 cites W2012561243 @default.
- W2066881823 cites W2012901990 @default.
- W2066881823 cites W2022756726 @default.
- W2066881823 cites W2035580449 @default.
- W2066881823 cites W2039735363 @default.
- W2066881823 cites W2044407202 @default.
- W2066881823 cites W2050647292 @default.
- W2066881823 cites W2057821737 @default.
- W2066881823 cites W2059304365 @default.
- W2066881823 cites W2059804089 @default.
- W2066881823 cites W2061739245 @default.
- W2066881823 cites W2063198655 @default.
- W2066881823 cites W2078566578 @default.
- W2066881823 cites W2087982057 @default.
- W2066881823 cites W2097259690 @default.
- W2066881823 cites W2098022922 @default.
- W2066881823 cites W2107844626 @default.
- W2066881823 cites W2114078421 @default.
- W2066881823 cites W2128879174 @default.
- W2066881823 cites W2155193822 @default.
- W2066881823 cites W2155653297 @default.
- W2066881823 cites W2162771723 @default.
- W2066881823 cites W2167257433 @default.
- W2066881823 cites W2169821755 @default.
- W2066881823 cites W218489374 @default.
- W2066881823 cites W2749203687 @default.
- W2066881823 doi "https://doi.org/10.1016/j.bbadis.2014.01.002" @default.
- W2066881823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24440525" @default.
- W2066881823 hasPublicationYear "2014" @default.
- W2066881823 type Work @default.
- W2066881823 sameAs 2066881823 @default.
- W2066881823 citedByCount "57" @default.
- W2066881823 countsByYear W20668818232014 @default.
- W2066881823 countsByYear W20668818232015 @default.
- W2066881823 countsByYear W20668818232016 @default.
- W2066881823 countsByYear W20668818232017 @default.
- W2066881823 countsByYear W20668818232018 @default.
- W2066881823 countsByYear W20668818232019 @default.
- W2066881823 countsByYear W20668818232020 @default.
- W2066881823 countsByYear W20668818232021 @default.
- W2066881823 countsByYear W20668818232022 @default.
- W2066881823 countsByYear W20668818232023 @default.
- W2066881823 crossrefType "journal-article" @default.
- W2066881823 hasAuthorship W2066881823A5003713761 @default.
- W2066881823 hasAuthorship W2066881823A5011533166 @default.
- W2066881823 hasAuthorship W2066881823A5017255080 @default.
- W2066881823 hasAuthorship W2066881823A5047847751 @default.
- W2066881823 hasAuthorship W2066881823A5066133855 @default.
- W2066881823 hasAuthorship W2066881823A5085401513 @default.
- W2066881823 hasBestOaLocation W20668818231 @default.
- W2066881823 hasConcept C111919701 @default.
- W2066881823 hasConcept C12554922 @default.
- W2066881823 hasConcept C130861313 @default.
- W2066881823 hasConcept C136238340 @default.
- W2066881823 hasConcept C142669718 @default.
- W2066881823 hasConcept C142724271 @default.
- W2066881823 hasConcept C1491633281 @default.
- W2066881823 hasConcept C177907266 @default.
- W2066881823 hasConcept C179104552 @default.
- W2066881823 hasConcept C185592680 @default.
- W2066881823 hasConcept C206767735 @default.
- W2066881823 hasConcept C27523624 @default.
- W2066881823 hasConcept C2776925932 @default.
- W2066881823 hasConcept C2777633098 @default.
- W2066881823 hasConcept C2778896982 @default.
- W2066881823 hasConcept C2779134260 @default.
- W2066881823 hasConcept C2779951007 @default.
- W2066881823 hasConcept C2780431358 @default.
- W2066881823 hasConcept C2993400109 @default.
- W2066881823 hasConcept C31705614 @default.
- W2066881823 hasConcept C41008148 @default.
- W2066881823 hasConcept C502032728 @default.
- W2066881823 hasConcept C55493867 @default.
- W2066881823 hasConcept C71924100 @default.
- W2066881823 hasConcept C86803240 @default.