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• W2066883617 startingPage "3399" @default.
• W2066883617 abstract "Schizosaccharomyces pombe cells respond to nutrient deprivation by altering G 2 /M cell size control. The G 2 /M transition is controlled by activation of the cyclin-dependent kinase Cdc2p. Cdc2p activation is regulated both positively and negatively. cdr2 + was identified in a screen for regulators of mitotic control during nutrient deprivation. We have cloned cdr2 + and have found that it encodes a putative serine-threonine protein kinase that is related to Saccharomyces cerevisiae Gin4p and S. pombe Cdr1p/Nim1p.cdr2 + is not essential for viability, but cells lacking cdr2 + are elongated relative to wild-type cells, spending a longer period of time in G 2 . Because of this property, upon nitrogen deprivationcdr2 + mutants do not arrest in G 1 , but rather undergo another round of S phase and arrest in G 2 from which they are able to enter a state of quiescence. Genetic evidence suggests thatcdr2 + acts as a mitotic inducer, functioning through wee1 + , and is also important for the completion of cytokinesis at 36°C. Defects in cytokinesis are also generated by the overproduction of Cdr2p, but these defects are independent of wee1 + , suggesting thatcdr2 + encodes a second activity involved in cytokinesis." @default.
• W2066883617 created "2016-06-24" @default.
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• W2066883617 date "1998-12-01" @default.
• W2066883617 modified "2023-09-27" @default.
• W2066883617 title "The<i>cdr2</i>⁺Gene Encodes a Regulator of G₂/M Progression and Cytokinesis in<i>Schizosaccharomyces pombe</i>" @default.
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• W2066883617 doi "https://doi.org/10.1091/mbc.9.12.3399" @default.
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