FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066885963> ?p ?o ?g. }

• W2066885963 endingPage "306" @default.
• W2066885963 startingPage "297" @default.
• W2066885963 abstract "Serine palmitoyltransferase (SPT) is the key enzyme for the biosynthesis of sphingolipids. It has been reported that oral administration of myriocin (an SPT inhibitor) decreases plasma sphingomyelin (SM) and cholesterol levels, and reduces atherosclerosis in apoE knockout (KO) mice. We studied cholesterol absorption in myriocin-treated WT or apoE KO animals and found that, after myriocin treatment, the mice absorbed significantly less cholesterol than controls, with no observable pathological changes in the small intestine. More importantly, we found that heterozygous Sptlc1 (a subunit of SPT) KO mice also absorbed significantly less cholesterol than controls. To understand the mechanism, we measured protein levels of Niemann-Pick C1-like 1 (NPC1L1), ABCG5, and ABCA1, three key factors involved in intestinal cholesterol absorption. We found that NPC1L1 and ABCA1 were decreased, whereas ABCG5 was increased in the SPT deficient small intestine. SM levels on the apical membrane were also measured and they were significantly decreased in SPT deficient mice, compared with controls. In conclusion, SPT deficiency might reduce intestinal cholesterol absorption by altering NPC1L1 and ABCG5 protein levels in the apical membranes of enterocytes through lowering apical membrane SM levels. This may be also true for ABCA1 which locates on basal membrane of enterocytes. Manipulation of SPT activity could thus provide a novel alternative treatment for dyslipidemia." @default.
• W2066885963 created "2016-06-24" @default.
• W2066885963 creator A5030114844 @default.
• W2066885963 creator A5031911087 @default.
• W2066885963 creator A5031930208 @default.
• W2066885963 creator A5035333297 @default.
• W2066885963 creator A5038805449 @default.
• W2066885963 creator A5055404631 @default.
• W2066885963 creator A5060479110 @default.
• W2066885963 creator A5065582421 @default.
• W2066885963 creator A5066507748 @default.
• W2066885963 creator A5074461919 @default.
• W2066885963 creator A5076268974 @default.
• W2066885963 date "2009-04-01" @default.
• W2066885963 modified "2023-09-25" @default.
• W2066885963 title "Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol☆" @default.
• W2066885963 cites W1967716147 @default.
• W2066885963 cites W1970055860 @default.
• W2066885963 cites W1982783177 @default.
• W2066885963 cites W1985425916 @default.
• W2066885963 cites W1986988638 @default.
• W2066885963 cites W1990394752 @default.
• W2066885963 cites W1997567789 @default.
• W2066885963 cites W2000823512 @default.
• W2066885963 cites W2001593674 @default.
• W2066885963 cites W2003374952 @default.
• W2066885963 cites W2005855999 @default.
• W2066885963 cites W2014959138 @default.
• W2066885963 cites W2019425261 @default.
• W2066885963 cites W2031990957 @default.
• W2066885963 cites W2034790783 @default.
• W2066885963 cites W2035556394 @default.
• W2066885963 cites W2043625150 @default.
• W2066885963 cites W2049469987 @default.
• W2066885963 cites W2054823361 @default.
• W2066885963 cites W2061165431 @default.
• W2066885963 cites W2062535842 @default.
• W2066885963 cites W2064752426 @default.
• W2066885963 cites W2069921134 @default.
• W2066885963 cites W2088649529 @default.
• W2066885963 cites W2090888958 @default.
• W2066885963 cites W2098023863 @default.
• W2066885963 cites W2099378835 @default.
• W2066885963 cites W2103273895 @default.
• W2066885963 cites W2108987650 @default.
• W2066885963 cites W2113284407 @default.
• W2066885963 cites W2119563325 @default.
• W2066885963 cites W2120579879 @default.
• W2066885963 cites W2121936687 @default.
• W2066885963 cites W2123936150 @default.
• W2066885963 cites W2133388060 @default.
• W2066885963 cites W2133495196 @default.
• W2066885963 cites W2146584630 @default.
• W2066885963 cites W2147040117 @default.
• W2066885963 cites W2156504663 @default.
• W2066885963 cites W2160650412 @default.
• W2066885963 cites W2164232957 @default.
• W2066885963 cites W2167444564 @default.
• W2066885963 cites W2167612600 @default.
• W2066885963 cites W2276828633 @default.
• W2066885963 doi "https://doi.org/10.1016/j.bbalip.2009.01.010" @default.
• W2066885963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4371774" @default.
• W2066885963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19416652" @default.
• W2066885963 hasPublicationYear "2009" @default.
• W2066885963 type Work @default.
• W2066885963 sameAs 2066885963 @default.
• W2066885963 citedByCount "23" @default.
• W2066885963 countsByYear W20668859632012 @default.
• W2066885963 countsByYear W20668859632013 @default.
• W2066885963 countsByYear W20668859632014 @default.
• W2066885963 countsByYear W20668859632015 @default.
• W2066885963 countsByYear W20668859632016 @default.
• W2066885963 countsByYear W20668859632019 @default.
• W2066885963 countsByYear W20668859632020 @default.
• W2066885963 countsByYear W20668859632021 @default.
• W2066885963 countsByYear W20668859632022 @default.
• W2066885963 crossrefType "journal-article" @default.
• W2066885963 hasAuthorship W2066885963A5030114844 @default.
• W2066885963 hasAuthorship W2066885963A5031911087 @default.
• W2066885963 hasAuthorship W2066885963A5031930208 @default.
• W2066885963 hasAuthorship W2066885963A5035333297 @default.
• W2066885963 hasAuthorship W2066885963A5038805449 @default.
• W2066885963 hasAuthorship W2066885963A5055404631 @default.
• W2066885963 hasAuthorship W2066885963A5060479110 @default.
• W2066885963 hasAuthorship W2066885963A5065582421 @default.
• W2066885963 hasAuthorship W2066885963A5066507748 @default.
• W2066885963 hasAuthorship W2066885963A5074461919 @default.
• W2066885963 hasAuthorship W2066885963A5076268974 @default.
• W2066885963 hasBestOaLocation W20668859632 @default.
• W2066885963 hasConcept C104317684 @default.
• W2066885963 hasConcept C126322002 @default.
• W2066885963 hasConcept C134018914 @default.
• W2066885963 hasConcept C149011108 @default.
• W2066885963 hasConcept C185592680 @default.
• W2066885963 hasConcept C2777704780 @default.
• W2066885963 hasConcept C2778163477 @default.
• W2066885963 hasConcept C2779134260 @default.
• W2066885963 hasConcept C55493867 @default.

• next