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• W2066907172 abstract "Replacement by alanine of Ser-948, Thr-974 and Lys-954 of Escherichia coli carbamoyl phosphate synthetase (CPS) shows that these residues are involved in binding the allosteric inhibitor UMP and the activator IMP. The mutant CPSs are active in vivo and in vitro and exhibit normal activation by ornithine, but the modulation by both UMP and IMP is either lost or diminished. The results demonstrate that the sites for UMP and IMP overlap and that the activator ornithine binds elsewhere. Since the mutated residues were found in the crystal structure of CPS near a bound phosphate, Ser-948, Thr-974 and Lys-954 bind the phosphate moiety of UMP and IMP." @default.
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• W2066907172 date "1999-03-05" @default.
• W2066907172 modified "2023-09-26" @default.
• W2066907172 title "Localization of the site for the nucleotide effectors of<i>Escherichia coli</i>carbamoyl phosphate synthetase using site-directed mutagenesis" @default.
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• W2066907172 doi "https://doi.org/10.1016/s0014-5793(99)00197-0" @default.
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